Abstract: Objective：To study the expression of stc2 in AFP positive gastric cancer and its prognostic value.Methods：Taking 112 AFP positive gastric cancer patients admitted to our hospital from March 2018 to June 2019 as the research object, another 112normal gastric cancer patients in the same period of physical examination in our hospital as the control group, respectively, to compare the expression of stc2 in cancer tissues, cancer tissues and normal mucosa, analyze the difference between the expression of stc2 in cancer tissues with different disease states, and compare the expression of stc2 with the expression of stc2 The correlation among the degree of differentiation, infiltration, lymph node metastasis and peritoneal metastasis was analyzed.Results：By comparing the expression of stc2 in three groups of tissues, the positive rate of stc2 from high to low was cancer tissue, paracancer tissue and normal mucosa tissue. By comparing the expression of stc2 in different pathological state of cancer tissue, there were statistically significant differences between the differentiation degree, infiltration degree（P＜0.05）; lymphatic metastasis and abdominal metastasis of different tumor tissue by correlation analysis, the positive expression of TC2 was positively correlated with the differentiation degree, infiltration degree, lymph metastasis and abdominal metastasis of different tumor tissues.Conclusion：The expression of stc2 in AFP positive gastric cancer tissue is significantly related to the prognosis of the patients.

Key words: gastric cancer, degree of invasion, lymphatic metastasis, abdominal metastasis, stanniocalcin2