Effect of pre-stored autotransfusion on inflammatory response and immune function in patients undergoing liver cancer surgery
JOURNAL OF CLINICAL SURGERY. 2021, 29 (11):
Objective To explore the effect of pre-stored autotransfusion on patients undergoing liver cancer surgery,as well as the effect on inflammation and immune function.
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Methods From June 2019 to February 2021,60 cases of liver cancer patients planned to undergo open partial liver resection in our hospital were selected,according to the different blood transfusion methods,they were divided into 30 cases in the control group using allogeneic blood transfusion and 30 cases in the observation group using pre-stored autotransfusion.Record the operation status of the two groups.The serum inflammatory response and immune function indexes of the two groups were tested before operation and 1,5 days after operation.
Results There was no significant difference between the two groups in operation and anesthesia time,urine volume,intraoperative blood loss(P>0.05).The levels of IL-2,CD3+,CD4+,CD4+/CD8+,NK,IgG,IgA,IgM in the control group 1,5 days after operation and in the observation group 1 day after operation were lower than those before operation,and the IL-10,CRP,TNF-α,CD8+ levels were higher than before operation,and the IL-2,CD3+,CD4+,CD4+/CD8+,NK,IgG,IgA,IgM levels in the observation group were higher than those in the control group at the same time period,the levels of IL-10,CRP,TNF-α and CD8+ were lower than those in the control group in the same time period(P<0.05).The incidence of complications of blood transfusion in the observation group (0) was lower than in the control group (13.34%,P<0.05).
Conclusion Pre-stored autotransfusion has little effect on the inflammation and immune function of patients undergoing liver cancer surgery,and has good safety.