Abstract: Objective:To analyze and evaluate the efficacy of laparoscopic sleeve gastrectomy（LSG）in the treatment of metabolic syndrome.Methods:The clinical data of 52 patients with metabolic syndrome who underwent LSG and completed regular followup in our hospital from June 2017 to June 2018，We recorded and compared the measurements of preoperation and postoperation，including：body weight，BMI，excess weight loss rate，waist、neck circumferences，blood lipid metabolism，blood glucose metabolism，changes in some biochemical indicators and improvement of comorbidities.Results:52 patients have complished regular follow up in 12 months after surgery，body weight，BMI decreased from （123.92±21.03）kg、（42.98±6.70）kg/m2  to （80.13±10.35） kg、（27.66±3.30）kg/m2 in 12 months after surgery，fasting blood glucose，glycosylated hemoglobin decreased from（6.64±1.95）mmol/L、（6.67±1.55）% to（4.17±0.56）mmol/L、（5.15±0.21）%.Triglyceride，lowdensity lipoprotein cholesterol decreased from（2.47±0.72）mmol/L、（3.03±0.71）mmol/L to（1.20±0.18）mmol/L、（2.05±0.48）mmol/L，the differences were statistically significant（P<0.05）.Most patients with metabolic syndrome and related comorbidities have been improved and/or cured after surgery in 12 months.Conclusion:LSG treatment of metabolic syndrome is safe，not only significantly reduce body weight but also improves or heals the metabolic syndrome and related comorbidities.

Key words: laparascopic sleeve gastrectomy, metabolic syndrome, comorbidity, efficacy