Abstract: Objective：To investigate the longterm efficacy and prognostic factors of minimally invasive esophagectomy of advanced esophageal cancer.Methods：The clinical data of 128 cases of advanced esophageal cancer minimally invasive esophagectomy were collected.The outcome measures included treatment，postoperative pathology，follow-up and prognostic factors.Onefactor analysis was conducted by χ2 test.The influencing factors of P<0.05 in Onefactor analysis were further included into cox regression model for multifactor analysis.Results：128 patients successfully completed the operation，and none of them were converted to open.The operation time of 128 patients was（287±61）min，and the intraoperative blood loss was（134±181）ml.The number of lymph node dissection in 128 patients was（21±8）per case，all of which were R0 resection；tumor diameter was（4.5±2.3）cm；The 5year overall survival rate of 128 patients was 24.2%，and the progressionfree survival rate was 18.0%.Univariate analysis showed that age，N stage，M stage and TNM stage were related factors affecting the 5year overall survival rate of postoperative minimally invasive esophagectomy；also，affecting 5year progressionfree survival rate.Multivariate analysis showed that N stage，M stage and TNM stage were independent influencing factors of 5year overall survival rate and progressionfree survival rate after minimally invasive esophagectomy of advanced esophageal cancer.Conclusion：The longterm results of minimally invasive esophagectomy of advanced esophageal cancer are satisfactory.The tumor N stage，M stage and TNM stage are independent factors affecting the overall survival rate and progressionfree survival rate of postoperative patients.

Key words: advanced esophageal cancer, minimally invasive esophagectomy, longterm efficacy, prognostic factors