Abstract: Objective To evaluate the clinical efficacy of scorpion venom active polypeptide gel in managing venous ulceration of lower extremities after stage C6 varicose vein surgery.Methods Thirty-six stage C6 varicose vein patients with lower limbs venous ulceration were randomly divided into two groups.All of which underwent varicose vein surgery.18 cases were in the control group，and the venous ulceration wound after surgery was managed with routine dressing change.The other 18 cases were in the scorpion venom active polypeptide gel group，the venous ulceration wound after surgery was covered with scorpion venom active polypeptide gel before changing dressings every other day.The size of the wound，wound infections and visual analogue score were evaluated at different time points during the treatment.Results There was no significant difference between two groups on general conditions（P>0.05）.The visual analogue scores related to venous ulceration wound showed no significant differences between two groups at 24 hours，48 hours and 72 hours after surgery（P>0.05）.Scorpion venom active polypeptide gel reduced wound infections markedly after surgery（P<0.05）.Meanwhile，the healing time in scorpion venom active polypeptide gel group was significantly shorter when compared with control group（21.7±7.9 d vs 29.4±8.6 d，P<0.01）.Conclusion Scorpion venom active polypeptide gel application accelerates wound healing process and inhibits infection when treating venous ulceration of lower limbs after stage C6 varicose vein surgery.

Key words: scorpion venom active polypeptide gel, venous ulceration, varicose vein, wound, efficacy