临床外科杂志 ›› 2020, Vol. 28 ›› Issue (9): 857-859.doi: 10.3969/j.issn.1005-6483.2020.09.019

• • 上一篇    下一篇

NOBp1表达水平与乳腺癌临床病理因素及预后相关性

  

  1. 572000 海南省三亚市中医院院感科(陈革),普外科(陈汉雄);海南省三亚中心医院 (侯本新)
  • 出版日期:2020-09-20 发布日期:2020-09-20
  • 通讯作者: 陈汉雄,Email:chenhanxiongchx@126.com

Correlation between NOBp1 expression and clinicopathological factors and prognosis of breast cancer

  1. Department of Hospital Infection Control,Sanya hospital of traditional chinese medicine,Hainan,Sanya 572000,China
  • Online:2020-09-20 Published:2020-09-20

摘要: 目的 探讨乳腺癌组织中NOBp1表达水平及其与病人临床病理因素、预后的相关性。
方法 2013年4月~2014年4月收治的乳腺癌病人90例,取切除的乳腺癌组织,使用免疫组织化学法(IHC)检测癌组织中NOBp1表达水平。随访截至2019年10月,分析NOBp1表达水平与病人临床病理因素及总生存期(OS)的相关性。
结果 90例病人中,NOBp1表达阳性者32例(35.6%),表达阴性者58例(64.4%)。NOBp1表达与病人淋巴结转移状态、肿瘤大小、TNM分期有相关性(P<0.05),与年龄、月经状态、分子分型差异无统计学意义(P>0.05)。截至2019年10月,病人失访5例,共85例获得随访,中位随访时间为49个月,OS 21~62个月,随访中有20例死亡。Kaplan-Meier分析显示,NOBp1表达阴性组病人OS较NOBp1表达阳性组更长(P=0.004)。单因素分析结果显示,肿瘤大小、淋巴结状态、肿瘤TNM分期、分子分型、NOBp1表达是影响乳腺癌病人OS的预后因素(P<0.05);多因素COX分析显示,淋巴结状态、肿瘤TNM分期、分子分型、NOBp1表达是影响乳腺癌病人OS的独立预后因素(P<0.05)。
结论 NOBp1表达水平升高病人OS较短,是乳腺癌预后的危险因素,NOBp1表达升高病人乳腺癌预后不良。

关键词: NOBp1, 乳腺癌, 总生存期, 预后

Abstract: Objective To investigate the expression of NOBp1 in breast cancer tissues and its correlation with clinicopathological factors and prognosis.
Methods A total of 90 patients with breast cancer admitted to our hospital from April 2013 to April 2014 were enrolled.Breast cancer tissues were taken and immunohistochemistry (IHC) was used to detect the expression of NOBp1 in cancer tissues.Followed up to October 2019,the correlation between NOBp1 expression level and clinical pathological factors and overall survival (OS) was analyzed.
Results Of the 90 patients,32 (35.6%) were positive for NOBp1 and 58 (64.4%) were negative for NOBp1.The expression of NOBp1 was correlated with lymph node metastasis status,tumor size and TNM stage (P<0.05),and there was no significant difference with age,menstrual status and molecular typing (P>0.05).As of October 2019,the patients were lost to follow-up in 5 patients.A total of 85 patients were followed up.The median follow-up time was 49 months,OS range:21~62 months,and 20 patients died during follow-up.Kaplan-Meier analysis showed that OS in the NOBp1 negative group was longer than the NOBp1 positive group (P=0.004).Univariate COX analysis showed that tumor size,lymph node status,TNM,molecular typing,NOBp1 expression were the prognostic factors affecting OS in breast cancer patients (P<0.05).Multivariate COX analysis showed lymph node status,TNM,Molecular typing and NOBp1 expression were independent prognostic factors affecting OS in breast cancer patients (P<0.05).
Conclusion Patients with elevated NOBp1 expression have shorter OS and are risk factors for breast cancer prognosis.Patients with elevated NOBp1 expression have poor prognosis.

Key words: NOBp1, breast cancer, overall survival, prognosis

[1] 高丹 郑媛 姜冉 陈波 田少林 王蓉 卢文亮. 乳房活检方式对前哨淋巴结活检的影响[J]. 临床外科杂志, 2020, 28(9): 848-851.
[2] 王波 董小林. 人G补缀FHA域血管生成因子1在三阴性乳腺癌的表达与预后的关系[J]. 临床外科杂志, 2020, 28(9): 860-863.
[3] 彭丰 王敏 谢昱 秦仁义. 长链非编码RNA SNHG1在胆管癌中的表达与临床特征及预后的相关性分析[J]. 临床外科杂志, 2020, 28(8): 725-727.
[4] 王韬 张峥嵘 王少圣 武健. 胆囊肉瘤样癌五例临床分析[J]. 临床外科杂志, 2020, 28(8): 744-746.
[5] 任宇 王刚乐. 麦默通旋切术用于乳腺癌病灶切除的临床价值[J]. 临床外科杂志, 2020, 28(8): 764-766.
[6] 郑丽华 吴尚 张晶 张泽鹏 王昕仪 杨天硕 赵亚恒 贺新奇 刘运江. 纤维蛋白原与三阴性乳腺癌总生存期的关系[J]. 临床外科杂志, 2020, 28(8): 767-770.
[7] 徐冉 杨年钊 赵海远 李阳 赵军 张义胜. 多灶性胃癌病人淋巴结转移危险因素及预后分析[J]. 临床外科杂志, 2020, 28(8): 774-777.
[8] 袁俊 李印 彭银杰 凃成志 陈威鹏 秦建军. 术前中性粒细胞与淋巴细胞比值对淋巴结转移的胸段食管鳞癌病人预后的预测价值[J]. 临床外科杂志, 2020, 28(7): 627-630.
[9] 李政委, 王杭州, 朱炳鑫等. 学龄前儿童中重型颅脑损伤预后不良相关因素分析[J]. 临床外科杂志, 2020, 28(6): 545-547.
[10] 于永政, 梁雪妍, 邢娴娴等. 乳腺癌荧光染料法腋窝反向淋巴作图的可行性及安全性研究[J]. 临床外科杂志, 2020, 28(6): 551-553.
[11] 韩加刚, 王振军. 梗阻性左半结肠癌治疗新策略-支架扩张联合新辅助化疗[J]. 临床外科杂志, 2020, 28(5): 401-403.
[12] 狄子杨, 唐强, 狄茂军等. 腹腔热灌注化疗治疗晚期结直肠癌的疗效分析[J]. 临床外科杂志, 2020, 28(5): 433-436.
[13] 蔡华霞, 王曙逢. 联合中性粒细胞/淋巴细胞比值与纤维蛋白原在分析胃肠道间质瘤预后中的价值[J]. 临床外科杂志, 2020, 28(5): 452-455.
[14] 查正彪, 潘友民, 郑智等. Stanford A型主动脉夹层术后急性肾功能损伤危险因素分析及预后[J]. 临床外科杂志, 2020, 28(5): 467-470.
[15] 王序杰, 周岩冰. 机器人直肠癌手术现状[J]. 临床外科杂志, 2020, 28(5): 489-492.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!