关键词: 纤维蛋白原, 三阴性乳腺癌, 总生存期

Abstract: Objective To explore the relationship between preoperative fibrinogen（FIB）and overall survival Overall Survival（OS）of women with triple negative breast cancer.
Methods A total of 295 women with triple-negative breast cancer treated in the Breast Center of the Fourth Hospital of Hebei Medical University from December 2009 to December 2012 were collected.A retrospective study was adopted，and Kaplan-Meier method and Cox proportional regression risk model were used for survival analysis.Log-rank test was used to analyze the differences between groups.To investigate the relationship between preoperative FIB expression and OS in female triple negative breast cancer patients.
Results X-Tile software was used to find the best cut-off value of FIB（g/L），and the patients were divided into two groups，FIB <3.7g/L group and FIB≥3.7g/L group.Using the Kaplan-Meier method for univariate analysis，OS was significantly reduced in the FIB≥3.7 group（HR，2.4，95% CI，1.1，4.9，P=0.002）; using the COX risk regression model for multivariate analysis，in the FIB≥3.7 group In addition，OS was also significantly reduced（HR，2.2，95% CI，1.1，4.6，P=0.028）.Kaplan-Meier survival curve results established by multivariate analysis showed that the higher the preoperative FIB value，the lower the OS.
Conclusion Low preoperative FIB expression is an independent prognostic factor for overall survival in women with triple negative breast cancer.

Key words: fibrinogen, triple negative breast cancer, overall survival