关键词: 人G补缀FHA域血管生成因子1, 三阴性, 乳腺癌, 预后

Abstract: Objective To investigate the prognostic significance of AGGF1,which plays an important role in tumor angiogenesis,and its expression in triple negative breast cancer.
Methods Immunohistochemistry and Western blot methods for AGGF1 expression in 102 triple negative breast cancer specimens were detected,study the correlation between AGGF1 expression and various pathologic factors and breast cancer survival.
Results There was positive correlation between the results of Immunohistochemistry and Western blot assay （r=0.859，P=0.00）.The expression of AGGF1 in triple negative breast cancer tissues was associated with Ki-67 expression（P<0.05）,but not with age,tumor size,TNM stage and lymph node metastasis（P>0.05）.The positive and negative expression of AGGF1 were observed in 42 and 60 of all 102 triple negative breast cancer patients.17 and 3 patients died in each group during the follow-up.The positive expression of AGGF1 was correlated with poorer overall survival than the negative expression group（P<0.05）.
Conclusion Positive expression of AGGF1 was poor prognostic factor in triple negative breast cancers.Further investigation is essential to determine whether AGGF1 might be effective therapeutic targets for triple negative breast cancer.

Key words: angiogenic factor with G and FHA domains 1; , triple negative, breast cancer, prognosis