Abstract: Objective To explore the predictive value of preoperative lymphocyte,C-reactive protein (CRP) and their ratio (LCR) on complications after laparoscopic radical resection of colorectal cancer.Methods The clinical data of 120 patients with colorectal cancer who received laparoscopic radical resection from October 2021 to October 2024 were retrospectively analyzed.Clavien-Dindo grading was used to evaluate the occurrence of postoperative complications.The patients were divided into complication group and control group.Multivariate logistic regression analysis of factors influencing the risk of postoperative complications.The predictive value of receiver operating characteristic (ROC) curve detection of influencing factors for postoperative complications.Results According to the follow-up results,there were 51 patients with Clavien-Dindo grade≥ Ⅱ within 30 days after surgery.The lymphocyte and LCR in complication group were lower than those in control group (P<0.05) while the CRP level was higher than that in control group (P<0.05).The results of univariate analysis showed that the LCR of the complication group was lower than that of the control group (P<0.05),the age and operation time of the complication group were higher than that of the control group (P<0.05),and the number of patients with diabetes and hypertension in the complication group was more than that in the control group (P<0.05).Multivariate logistic regression analysis,LCR、Age,diabetes and operation time were independent risk factors for postoperative complications (P<0.05).ROC curve analysis showed that the AUC of preoperative LCR index,age,diabetes,hypertension,and operation time were 0.934,0.645,0.604,0.631,0.821,respectively,the sensitivity was 92.75%,52.94%,41.18%,39.22%,80.39%,and the specificity was 88.24%,66.67%,79.71%,86.96%,75.36%,respectively.Conclusion The decrease of LCR is related to the occurrence of postoperative complications in patients undergoing laparoscopic radical resection of colorectal cancer.

Key words: colorectal cancer, laparoscopic radical resection, lymphocyte, C-reactive protein