Abstract: Objective To explore the predictive value of preoperative C-reactive protein albumin lymphocyte(CALLY) index on prognosis of surgical treatment in esophageal cancer(EC) patients.Methods From January 2020 to June 2024, 120 patients with EC underwent radical resection.Collect the patient's whole blood cell count,albumin,total lymphocyte count,CRP level,and tumor markers one week before surgery,and calculate the CALLY index.Analyze its correlation with disease-free survival(DFS),overall survival(OS),and surgical site infection(SSI).Results Elderly patients(≥69 years old),patients receiving neoadjuvant chemotherapy,patients with lymphatic infiltration,patients with advanced T stage(T3/4), patients with lymph node metastasis had lower preoperative CALLY index,and the difference was statistically significant（P<0.05).Multivariate analysis showed that low preoperative CALLY index was an independent risk factor for decreased OS and DFS in EC patients;low preoperative CALLY index was an independent risk factor for postoperative SSI in EC patients（P<0.05).Conclusion The preoperative CALLY index can serve as a predictive factor for the prognosis of esophageal cancer patients undergoing surgical treatment.

Key words: C-reactive protein; albumin; lymphocyte index; esophageal cancer