JOURNAL OF CLINICAL SURGERY ›› 2022, Vol. 30 ›› Issue (12): 1143-1146.doi: 10.3969/j.issn.1005-6483.2022.12.014

Previous Articles     Next Articles

Optimization of anesthesia protocol for intestinal obstruction and analysis of the differential effects on intestinal barrier function,oxidative stress,and inflammatory response

  

  1. Department of Anesthesiology,Second Affiliated Hospital of Air Force Military Medical University,Shanxi,Xi'an 710038,China
  • Received:2022-06-29 Accepted:2022-06-29 Online:2022-12-20 Published:2023-01-20

Abstract: Objective To investigate the differential effects of the optimization of anesthesia protocols on intestinal barrier function,oxidative stress,and inflammatory response in patients with intestinal obstruction.Methods Ninety-three patients receiving intestinal obstruction surgery in our hospital from January 2019 to January 2022 were enrolled,and classified into two groups according to different anesthesia methods.Control group(n=53) received routine general anesthesia,while experimental group(n=40) received  general anesthesia combined with transverse abdominal plane(TAP) + rectus sheath block block.Then comparison was conducted on intestinal barrier function [diamine oxidase(DAO) activity and endotoxin(ETX)],oxidative stress [catalase(CAT) and epinephrine],inflammatory response [tumor necrosis factor-α(TNF-α) and interleukin6(IL-6)],along with the postoperative time of first anal exhaust,defecation and out-of-bed activity.Results Compared with control group,experimental group had lower intraoperative sufentanil consumption,and shorter postoperative time of first anal exhaust and defecation(all P<0.05).Compared with baseline data,an increase in DAO activity,ETX,TNF-α,IL-6 and epinephrine levels along with a decrease in CAT were observed in both groups at postoperative 1 d and 3 d(all P<0.05).Compared with control group,experimental group had higher DAO activity,ETX,TNF-α,IL-6 and epinephrine levels,and lower CAT levels at postoperative 1 d and 3 d,with statistical difference(all P<0.05).Conclusion Compared with other anesthesia protocol,general anaesthesia combined with TAP + rectus sheath block is more effective for patients receiving intestinal obstruction surgery,which cause less impact on intestinal barrier function and oxidative stress,and can attenuate the inflammatory response.

Key words: intestinal obstruction, anesthesia protocol, intestinal barrier function, oxidative stress, inflammatory response

[1] LUO Yaobing, YANG Wujun, WANG Xingping, et al. Effect of stepped decompression under intracranial pressure monitoring on inflammatory response,metabolic status and prognosis of patients with emergency craniocerebral trauma [J]. JOURNAL OF CLINICAL SURGERY, 2022, 30(7): 640-643.
[2] LIANG Wenjie, LI Ran, FENG Jiangmian, et al. Effect of modified Karl-Storz single-port laparoscopic surgery on acute appendicitis and its effect on immune function and inflammatory response [J]. JOURNAL OF CLINICAL SURGERY, 2022, 30(12): 1155-1158.
[3] XU Weijie, LI Jinyu, LIN Lianzheng, et al.. Effect of transurethral plasma ERBT on blood loss and oxidative stress factors in patients with NMIBC [J]. JOURNAL OF CLINICAL SURGERY, 2022, 30(12): 1187-1190.
[4] . Clinical study of microwave ablation in the treatment of advanced lung adenocarcinoma [J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(8): 722-725.
[5] . The application of compound PanPrayglucamine in diagnosis and treatment of intestinal obstruction [J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(2): 151-153.
[6] LI Zhuwei, YIN Dongliang, LI Xiaolan, et al.. Effect of pre-stored autotransfusion on inflammatory response and immune function in patients undergoing liver cancer surgery [J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(11): 1034-1037.
[7] ZHANG Xifeng, CHEN Lingling, AN Hongqiang, et al.. Effects of different doses of dexmedetomidine on agitation and oxidative stress reaction after abdominal surgery in children [J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(11): 1083-1085.
[8] . Study on the application effect of palliative stenting in patients with advanced colon cancer [J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(5): 429-432.
[9] SHI Fei, SHI Liuhui, SHI Bowen, et al.. Clinical study of carboxymethyl chitosan rinse in preventing infectious complications after ureteroscopy [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(8): 689-692.
[10] . The application of fast track surgery in colon cancer patients with intestinal obstruction [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(5): 404-407.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. JOURNAL OF CLINICAL SURGERY, 2017, 25(1): 51 .
[2] FENG Jinteng, FAN Kun, ZHANG Guangjian, et al.. Retrospective analysis of 202 cases with esophageal foreign bodies[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(9): 683 -685 .
[3] ZHANG Tao, ZHANG Xiaoming. Treatment of renal carcinoma complicated by inferior vena cava tumor thrombus[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(11): 801 -804 .
[4] LIN Peida, HUANG Jiaqi, LU Huaxiang, et al. Safety and early efficacy analysis of pharmacomechanical thrombectomy for the treatment of trauma patients with lower extremity deep venous thrombosis[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(11): 810 -813 .
[5] JIANG Hui, ZHANG Xue, LI Shiyong, et al.. Diagnosis and treatment of negative pressure pulmonary edema(NPPE)during general anesthesia recovery period[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(11): 868 -870 .
[6] LIU Haifeng, ZHAO Xiaoqiang, PAN Feilong. Effect of rehabilitation training intervention on the prognosis of tibial plateau fracture patients treated by internal fixation[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(11): 874 -877 .
[7] . Effect of donation after cardiac death donor quality on receptor survival rate after liver transplantation and analysis of risk factors of infection[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(12): 913 -916 .
[8] . Application of HLA Epitope in tissue matching of renal transplantation[J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(12): 980 -983 .
[9] LI Donghang, YAO Yi, GENG Qing. Interpretation of the update of the guideline for the comprehensive diagnosis and treatment of liver cancer(2018 edition)[J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(1): 36 -39 .
[10] . [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(2): 95 .