Abstract:   Objective  To explore the diagnosis and treatment of NPPE during general anesthesia recovery period.Methods  A retrospective investigation of clinical manifestation，imageology，clinical course and outcome of 16 cases with NPPE.  Results  All these cases presented with tachypnea，dyspnea，oxygen desaturation，rales and frothy sputum in few minute after upper airway obstruction.12 cases was performed endotracheal intubation and were admitted to the ICU,four patients had no intubation.The duration of mechanical ventilation was less than 8 hours in 10 cases and 12 hours in two.Four patients were treated with oxygen inhalation，whose symptoms were obviously improved in 6 to 8 hours.In 12 cases chest radiography was performed and showed bilateral diffuse infiltrates.4 cases displayed diffuse infiltrates in right lung.〖WTHZ〗Conclusion〖WTBZ〗〓NPPE is easily occurred in male，ASAI yong patients.The severity of NPPE is depended on obstruction of time.The main treatment of NPPE are symptomatic treatment，oxygen therapy timely with or without mechanical ventilation.Airway obstruction during general anesthesia recovery should be vigilant NPPE.

Key words: negative pressure pulmonary edema, ostobstructive pulmonary edema, general anesthesia recovery, airway obstruction