Abstract: Objective To investigate the clinical effect of laparoscopic chole-cystectomy(LC),laparoscopic forward intubation through cystic duct combined with duodenoscope and intraoperative ultrasound in the one-stage treatment of cholecysto-lithiasis and thining choledocholithiasis. Methods Retrospective cohort study was performed to analyze the clinical data of 108 cases of cholecystolithiasis complicated with thining choledocholithiasis from June 2019 to August 2020.The 34 patients who underwent laparoscopic intubation through the the cystic duct duct during laparoscope,duodenoscope and intraoperative ultrasound were allocated into the study group,and the remaining 74 patients received treatment by laparoscope combined with duodenoscope were assigned to the control group. Results Both groups underwent laparoscopic cholecystectomy successfully.The intubated was successfully inserted via cystic duct into the duodenal papilla.Eight patients in the control group were failed to ERCP treatment.Instead,they were successfully treated with the study group treatment.Seven patients in the control group developed mild pancreatitis,while no pancreatitis was found in the study group.In the control group,3 cases possessed residual stones and the study group had 1 case.There was 1 case of duodenal perforation in the control group,and which was improved through surgical treatment.All 108 patients were followed up for 2-14 months, with a median follow up time of 7 months. No stone recurrence or death occurred. Conclusion Laparoscopic cholecystectomy,laparoscopic forward intubation through cystic duct combined with duodenoscope and intraoperative ultrasound for the one-stage treatment of cholecystolithiasis and thining choledocholithiasis are safe,effective and feasible.

Key words: cholelithiasis, choledocholithiasis, laparoscopy, duodenoscope, laparoscopic ultrasound