Abstract: Objective To study the clinical efficacy of  laparoscopic cholecystectomy under different time windows in the treatment of  mild biliary pancreatitis. Methods A total of  80 patients who were admitted with a diagnosis of mild biliary pancreatitis and underwent laparoscopic cholecystectomy at Nanjing Tongren hospital affiliated medical college of southeast university between February 2012 and February 2020 were selected randomly by digital random table method.After admission,Patients were divided into early surgery group and late surgery group according to operation time,with 40 cases in each group abdominal pain symptoms.Among them,LC treatment was performed after partial relief of abdominal pain in patients in the early surgery group,and LC treatment was performed after complete relief of abdominal pain in patients in the late surgery group.The clinical efficacy of the two groups was compared. Results The mean preoperative onset time between the two groups [(3.73±0.78) days vs.(6.88±1.07) days],and the difference was statistically significant(P<0.05).The conversion rate of open operation(5.0% vs.7.5%),operation time [(72.92±10.48) minutes vs.(74.02±9.94) minutes] and incidence of postoperative complications(5.0% vs.2.5%),there was no statistical significance between the two groups(P>0.05).Compared with the early surgery group,patients in the late surgery group had less intraoperative blood loss[(42.13±12.90)ml vs.(35.25±13.01)ml] and longer hospital stay [(7.73±0.78) days vs.(10.88±1.07) days]and increased hospitalization costs [(24 553.91±3 946.91) yuan vs.(27 617.96±4 276.29) yuan](all P<0.05).Although the difficulty of gallbladder triangle anatomy increased between the two groups,there was no significant difference in the rate of conversion to open surgery(P>0.05). Conclusion Early surgery for mild biliary pancreatitis does not  increase the perioperative complications and the conversion rate to open surgery,but it can significantly shorten the length of hospital stay,and reduce the economic burden of patients.

Key words: mild biliary pancreatitis, laparoscopic cholecystectomy, time of operative