Abstract: Objective To investigate the results of bacteria from bile culture with obstructive jaundice patients without clinical infection. Methods 136 cases from bile culture with obstructive jaundice patients without clinical infection were reviewedfrom January 2015 to December 2020.Bacterial culture was performed on bile retained during endoscopic retrograde cholangiopanchography (ERCP), percutaneous hepatic bile drainage (PTCD), and univariate and multivariate Logistic regression to analyse risk factors of positive bile culture. Results The total positive rate was 60.3%(82/136),in which malignant obstructive jaundice accounted 67.8%(59/87)and benign obstructive jaundice accounted 46.9%(23/49).14 strains bacteria were detected in 136 patients,which consisted of 6 strains of Gram-negative bacteria and 7 strains of Gram-positive bacteria,and 1 strain of fungus(candida albicans).The most common bacteria were Escherichia Coli,Enterococcus faecalis.The nature, site, time and degree of biliary obstruction were the risk factors for positive culture of bile bacteria(P<0.05). Conclusion The rate of positive bile culture was higher in obstructive jaundice patients without clinical infection,so it was necessary to use preventive antibiotics.

Key words: without clinical infection, obstructive jaundice, bile culture