Abstract: Objective To explore short-term curative effect of thoracoscopic-laparoscopic intrathoracic anastomosis（Ivor-Lewis）and neck anastomosis（McKeown）on thoracic middle-lower segment esophageal cancer.
Methods A total of 110 patients with thoracic middle-lower segment esophageal cancer who were admitted to the hospital from February 2016 to April 2018 were enrolled.According to different surgical methods，they were divided into two groups.Fifty-two patients in Ivor-Lewis group were treated with thoracoscopic-laparoscopic Ivor-Lewis，while fifty-eight patients in McKeown group were treated with thoracoscopic-laparoscopic McKeown.The perioperative surgical related indexes and complications were compared between the two groups.The lung function in both groups was evaluated before surgery and after 10d of surgery.Quality of Life Questionnaire-Oesophagus 18（QLQ -OES18）was applied to assess quality of life in both groups before surgery and after 4 weeks of surgery.
Results There were no significant differences in perioperative indexes such as operation time and hospitalization time between the two groups（P＞0.05）.After 6 months of surgery，there were no significant differences in lymph node metastasis and tumor recurrence between the two groups（P＞0.05）.After 10d after surgery，FEV1/FVC，FEV1 predicted value，PaO₂ and SaO₂ in both groups were significantly higher than those before surgery（P＜0.05）.After 4 weeks of surgery，scores of difficulty eating，coughing and speech in Ivor-Lewis group significantly lower than those in McKeown group（P＜0.05）.After 4 months of surgery，difficulty eating scores in both groups were significantly lower than those before surgery（P＜0.05），while scores of reflux，cough and speech were significantly higher than those before surgery（P＜0.05）.
Conclusion The tumor clearance effects of thoracoscopic-laparoscopic Ivor-Lewis and McKeown are similar in treatment of thoracic middle-lower segment esophageal cancer.However，incidence of complications is lower in patients treated with the former，lung function recovery is better，and quality of life is higher，whose short-term curative effect is more advantageous.

Key words: Thoracoscope, Laparoscope, Intrathoracic anastomosis, Neck anastomosis, Esophageal cancer