Abstract: Objective:To evaluate the nutritional status，immune function and clinical effectiveness of early enteral immunonutrition in elderly patients receiving totally endoscopic esophagectomy.Methods:This randomized controlled trial enrolled 96 patients receiving totally endoscopic esophagectomy in Department of Thoracic Surgery of The Fourth Hospital of Hebei Medical University between May 2015 and June 2017.The patients were randomly divided into enteral immunonutrition group（EIN group，n=47）and common enteral nutrition group（EN group，n=49）.Both groups received enteral nutrition through jejunostomy tube.Before operation and 1，3，7day after operation，the levels of nutritional indexes and immune indexes were compared，the time of first postoperative anal exhaust，the number of postoperative infections and the length of hospitalization were also compared between the two groups.Results:On the first day after operation，the nutritional indexes and immune indexes of the two groups were significantly lower than those before operation（all P<0.05）；On the 3th day after operation，the indexes of the two groups were increased（all P<0.05）；On the 7th day after operation，the rate of EIN group was faster than that of EN group（P<0.05）.There were no significant differences in the time of first postoperative anal exhaust and the length of hospitalization（P>0.05）.The number of postoperative pneumonia complications and the length of hospital stay were statistically significant（P<0.05）.Conclusion:Enteral immunonutrition can improve the nutritional status and the immune response，promote the rapid recovery in elderly patients receiving totally endoscopic esophagectomy.

Key words: enteral immunonutrition, thoracoscopy, laparoscopy, esophageal cancer