Abstract: Objective:To explore the effect of intraperitoneal hyperthermic perfusion chemotherapy（HIPEC）on the clinical efficacy and prognosis of patients with peritoneal metastasis of advanced colorectal cancer（CRC）.Methods:A retrospective analysis of 71 patients with CRC peritoneal metastasis from 2016.4 to 2017.4.All the patients were randomly divided into the observation group（34 cases）and control group（37 cases）according to different postoperative treatment.Patients in observation group were treated with intraperitoneal hyperthermic perfusion chemotherapy，and patients in the control group were treated with conventional chemotherapy regimens.After 6 courses of treatment，clinical efficacy，related indicators of recurrence and metastasis，tumor markers，quality of life，and occurrence of adverse reactions after chemotherapy were compared between the two groups.Results:The total effective rate（67.6%）and disease control rate（87.3%）in the observation group were significantly higher than total effective rate（40.5%）and disease control rate（62.2%）in the control group（P<0.05）.After the treatment，the levels of serum carbohydrate antigen 199（CA199）（24.21±1.98），CA125（37.97±2.93），and carcinoembryonic antigen（CEA）（16.26±2.02）in the observation group were significantly lower than the levels of serum carbohydrate antigen 199（CA199）（30.9±3.05），CA125（44.53±3.34），and carcinoembryonic antigen（CEA）（19.68±1.94）in the control group（P< 0.05）.The KPS score was significantly improved，and the 3year survival rate were significantly better in the observation group than in the control group（P<0.05）.There was no significant difference in the incidence of complications between the two groups（P>0.05）.Conclusion:Intraperitoneal hyperthermic chemotherapy can significantly improve the clinical efficacy of chemotherapy in patients with CRC，and effectively control tumor progression and improve the immune function.It will provide novel methods and approaches for the effective treatment of advanced colorectal cancer.

Key words: colorectal cancer, 〓peritoneal metastasis, 〓hyperthermia chemotherapy, 〓immune function, 〓prognosis