Abstract: Objective To evaluate the prognostic values of preoperative and postoperative serum inflammation-related indexes，including AGR，CAR and OPNI in patients with resected colorectal cancer.Methods The clinicopathological data，inflammation-related indexes and prognosis of colorectal cancer patients before and 1 month after operation were analyzed.Cox regression was applied to estimate the independentassociation of inflammationrelated indexes with progression-free survival and overall survival.Results A total of 509 colorectal cancer patients were included in this study.166 patients developed cancer progression and 80 died.Multivariate Cox regression showed that preoperative AGR（HR=1.58，95%CI 1.01 to 2.48），CAR（HR=1.72，95%CI 1.08 to 2.74）and OPNI（HR=1.51，95%CI 1.06 to 2.15），and postoperative CAR（HR=1.79，95%CI 1.14 to 2.85）and OPNI（HR=1.64，95%CI 1.04 to 2.60）were independent prognostic factors for PFS.Preoperative AGR（HR=2.58，95%CI 1.49 to 4.47）and OPNI（HR=1.84，95%CI 1.09 to 3.13），and postoperative CAR（HR=3.03，95%CI 1.61 to 5.69）and OPNI（HR=2.31，95%CI 1.30 to 4.13）were independent prognostic factors for OS.Conclusions Inflammation-related indexes before and 1 month after tumor resection can be used as independent prognostic markers of progression-free survival and overall survival in colorectal cancer patients.

Key words: Colorectal cancer, Inflammation-related indexes, Progression-free survival, Overall survival