Abstract: Objective：Correlation analysis of Inflammationbased prognostic scores（IPS）in survival rate after rectal cancer surgery.Methods：A retrospective cohort was used to analyze the patients who underwent radical resection of rectal cancer.A total of 678 patients were enrolled.Peripheral venous blood routine and liver function on the second day after admission，the inflammation scores  NLR，DNLR，PLR，LMR，COPNLR and PNI were calculated in turn，based on widely accepted inflammatory prognosis scores.（IPS），which calculates their respective scores in turn.The 5year survival time was used as the endpoint of the inflammatory prognostic score（IPS）.The index of the index（ROC）was used as the cutoff point for predicting the 5year survival time of the preoperative inflammatory prognostic score（IPS）.According to the threshold，the patients were divided into highinflammation prognostic score（IPS）group and lowinflammation prognosis score（IPS）group.The surgical methods，tumor TNM stage，tumor size and morphology，and invasion were compared between the two groups.And the relationship between the depth，the distance of the tumor from the anal margin，and other indicators.Then，the COX proportional hazard regression model was used to analyze the factors that constitute the inflammatory prognostic score（IPS）by univariate and multivariate analysis.Results：The area under the receiver operating characteristic curve for IPS diagnosis of death risk events（ROCAUX）was 0.781 and the cutoff point was 2.5.According to the 2.5 intercept points，it is divided into low IPS group and high IPS group.The age of the two groups was（59.1±11.9）years and（59.5±9.8）years，respectively.There was a statistically significant difference in TNM staging between the two groups.The multivariate COX risk regression model showed male，NLR，DNLR and COPNLR score as risk factors，and HR were 1.489，4.027，2.208 and 2.188，respectively.The LMR score was a protective factor with an HR of 0.559.Conclusion：Preoperative inflammatory outcome score（IPS）is associated with postoperative survival in rectal cancer.High inflammatory prognostic score（IPS）suggests a poor prognosis.

Key words: rectal carcinoma, inflammatory cell, nutritional index, prognosis