临床外科杂志 ›› 2023, Vol. 31 ›› Issue (12): 1160-1163.doi: 10.3969/j.issn.1005-6483.2023.12.014

• 论著 • 上一篇    下一篇

miR-539-5p、CAAP1在胃癌组织中的表达及临床意义

  

  1. 710054 西安市第九医院消化内科(黄小平、李萍)，血管介入科(李轶)
  • 收稿日期:2023-02-02 出版日期:2023-12-20 发布日期:2023-01-15
  • 通讯作者: 李萍，Email:vlqmtui593306@163.com
  • 基金资助:
    西安市第九医院科研项目(编号：2020-7)

Expression and clinical significance of miR-539-5p and Caspase activity and apoptosis inhibitory factor 1 in gastric cancer tissue

  1. Department of Gastroenterology,  Xi ’an Ninth Hospital, Shaanxi,Xi’an 710054, China
  • Received:2023-02-02 Online:2023-12-20 Published:2023-01-15

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摘要： 目的 探讨微小RNA(miR)-539-5p、Caspase活性和凋亡抑制因子1(CAAP1)在胃癌组织中表达及其临床意义。方法 2018年1月～2019年12月我院接受手术治疗胃癌组织标本及对应的癌旁组织102例，检测癌组织miR-539-5p、CAAP1表达水平，探讨miR-539-5p、CAAP1表达与临床病理参数及预后的关系。Pearson法分析miR-539-5p与CAAP1表达相关性。Kaplan-Meier法分析胃癌病人生存期。采用Cox回归模型分析胃癌病人预后的影响因素。结果 胃癌组织中miR-539-5p表达水平低于癌旁组织，CAAP1表达水平高于癌旁组织，差异有统计学意义(P<0.05)。胃癌组织miR-539-5p与CAAP1表达水平存在负相关性(P=0.000)。胃癌组织miR-539-5p、CAAP1表达均与TNM分期、浸润深度、淋巴结转移、肿瘤直径显著相关(P<0.05)。miR-539-5p高表达组3年生存率高于低表达组(P=0.045)，CAAP1高表达组3年生存率低于低表达组，差异有统计学意义(P=0.015)。Cox回归显示，TNM分期、浸润深度、淋巴结转移以及miR-539-5p、CAAP1表达是胃癌病人预后影响因素(P<0.05)。结论 miR-539-5p在胃癌组织中表达水平降低、CAAP1表达水平升高，与TNM分期、浸润深度、淋巴结转移、肿瘤直径有关，且二者与病人预后密切相关。

关键词: 胃癌, 微小RNA-539-5p, Caspase活性和凋亡抑制因子1

Abstract:

Objective To investigate the expression and clinical significance of microRNA (miR)-539-5p, Caspase activity and apoptosis inhibitory factor 1 (CAAP1) in gastric cancer tissue. Methods The gastric cancer tissue specimens and corresponding adjacent tissues of gastric cancer patients (102 cases) who underwent surgery in Xi ’an Ninth Hospita from January 2018 to December 2019 were collected, and the expression levels of miR-539-5p and CAAP1 in the tissues were detected and compared. The relationship between the expression of miR-539-5p and CAAP1 and clinicopathological parameters and prognosis was explored. The correlation between miR-539-5p and CAAP1 expression was analyzed by Pearson method. Kaplan-Meier method was used to analyze the survival time of gastric cancer patients. Cox regression model was used to analyze the prognostic factors of patients with gastric cancer. Results The expression level of miR-539-5p in gastric cancer tissue lower than that in adjacent tissue, and the expression level of CAAP1 higher than that in adjacent tissue (P<0.05). There was a negative correlation between the expression levels of miR-539-5p and CAAP1 in gastric cancer tissue (P=0.000). Further analysis showed that the expression of miR-539-5p and CAAP1 in gastric cancer tissue was greatly correlated with TNM stage, depth of invasion, lymph node metastasis and tumor size (P<0.05). The 3year survival rate of miR-539-5p high expression group was higher than that of low expression group (P=0.045). The 3year survival rate of CAAP1 high expression group which was lower than low expression group (P=0.015). Cox regression showed that TNM stage, depth of invasion, lymph node metastasis and miR-539-5p and CAAP1 expression were prognostic factors in patients with gastric cancer (P<0.05). Conclusion The decreased expression level of miR-539-5p and increased expression level of CAAP1 in gastric cancer tissues were related to TNM staging, depth of invasion, lymph node metastasis and tumor size, and they are closely related to the prognosis of patients.

Key words: gastric cancer, microRNA-539-5p, Caspase activity and apoptosis inhibitory factor 1

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