临床外科杂志 ›› 2023, Vol. 31 ›› Issue (11): 1057-1060.doi: 10.3969/j.issn.1005-6483.2023.11.015

• 论著 • 上一篇    下一篇

胃癌组织中ARHGAP4、FBLN5的表达及与病人预后的关系

  

  1. 050000  河北省石家庄市人民医院普外科一病区（周谦、孟宁、郝向东），核医学科 （刘晟楠）
  • 收稿日期:2022-12-29 修回日期:2022-12-29 接受日期:2022-12-29 出版日期:2023-11-20 发布日期:2023-11-20
  • 基金资助:
    石家庄市科技计划项目（181200963）

Expression of ARHGAP4 and FBLN5 in gastric cancer tissues and the relationship with patient prognosis

  1. Department of General Surgery Ward 1, Shijiazhuang People’s Hospital,Hebei,Shijiazhuang 050000,China
  • Received:2022-12-29 Revised:2022-12-29 Accepted:2022-12-29 Online:2023-11-20 Published:2023-11-20

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摘要： 目的  探讨扣针蛋白5(FBLN5)、Rho GTPase激活蛋白4(ARHGAP4)在胃癌组织中的表达及与病人预后的关系。方法  2013年12月～2018年12月我院收治的胃癌病人100例，收集距肿瘤边缘>1cm处的胃癌组织以及距肿瘤边缘>5cm的癌旁组织。分析FBLN5与ARHGAP4表达情况与胃癌临床病理学指标的关系，以及其对生存状况的影响，对病人的临床资料进行单因素和多因素Cox回归分析。采用免疫组织化学染色法检测FBLN5和ARHGAP4的表达情况。利用Kaplan-Meier法分析不同ARHGAP4、FBLN5表达水平与病人生存时间的关系。结果 胃癌组织ARHGAP4阳性表达率低于癌旁组织，FBLN5的阳性表达率高于癌旁组织(P＜0.05)；ARHGAP4表达与肿瘤部位、Lauren分型、淋巴结转移、TNM分期、分化程度、CEA、CA19-9、CA125、免疫评分有关(P<0.05)；FBLN5表达与Lauren分型、淋巴结转移、TNM分期、分化程度、CE、CA19-9、CA125、免疫评分有关(P<0.05)；FBLN5高表达组病人3年累积生存率低于低表达组(P=0.044)；ARHGAP4高表达病人3年累积生存率高于低表达病人(P=0.021)；Cox分析结果显示，ARHGAP4高表达为影响生存的保护因素(P<0.05)。结论 FBLN5高表达组病人预后较低表达病人差，ARHGAP4低表达病人预后较高表达病人好。FBLN5高表达为影响生存的危险因素，二者与胃癌病人病情发展和预后密切相关。

关键词: 胃癌, 扣针蛋白5, Rho GTPase激活蛋白4, 临床病理特征

Abstract: Objective To investigate the correlation of fibulin 5(FBLN5) and Rho GTPase activating protein 4(ARHGAP4) in gastric cancer tissues and their relationship with the prognosis of patients.Methods One hundred gastric cancer patients admitted to the Department of General Surgery of Shijiazhuang First Hospital were selected for the study,and gastric cancer tissues >1cm from the tumor margin and paracancerous tissues 5cm from the tumor margin were collected.Retrospective analysis of the relationship between FBLN5 and ARHGAP4 expression profiles and clinicopathological indices of gastric cancer,as well as their effects on survival,was performed with univariate and Cox regression analyses of the patients’ clinical data.Immunohistochemical staining was used to detect the expression of FBLN5 and ARHGAP4.The relationship between the expression levels of different FBLN5 and ARHGAP4 and the survival time of patients.Results The positive expression rate of ARHGAP4 was lower than that of paracancerent tissues,and the positive expression rate of FBLN5 was higher than that of paracancerent tissues(P<0.05).ARHGAP4 expression was associated with tumor site,Lauren’s staging,lymph node metastasis,TNM stage,differentiation degree,CE,CA19-9,CA125,and immune score(P<0.05);FBLN5 expression was associated with Lauren’s staging,lymph node metastasis,TNM stage,differentiation degree,CE,CA19-9,CA125,and immune score(P<0.05);Kaplan-Meier analysis showed that the 3-year cumulative survival rate of FBLN5 positive group was,which was lower than that of negative group(P=0.044).The 3-year cumulative survival rate of ARHGAP4 positive patients was higher than that of negative patients(P=0.021).Cox results showed that positive ARHGAP4 was protective factor for survival(P<0.05).Conclusion The prognosis of patients in the FBLN5-positive group is worse than that in the negative group,high expression of FBLN5 is a risk factor for survival,and the prognosis of patients with ARHGAP4 negative group is better than that in the positive group,which are closely related to the development and prognosis of gastric cancer patients.

Key words: gastric cancer, fibulin 5, Rho GTPase activating protein 4, clinicopathological features

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