关键词: 纤维蛋白原, 胃癌, Meta分析, 预后

Abstract: Objective   To explore the value of preoperative fibrinogen and the prognosis of non metastatic gastric cancer.  Methods   From the start of the library to May 31, 2022,by searching PubMed、EMBASE、Web of Science、Cochrane Library to determine the studies to evaluate the prognostic role of Fib in GC.Revman software(version 5.4) was used for data analysis.The hazard ratio(HR) with 95% confidence interval(CI) was used to evaluate the correlation between Fib and overall survival(OS) and recurrence free survival(RFS) in GC patients.  Results   This study included 8 retrospective studies,including 3999 patients.Meta analysis showed that the higher Fib value was associated with the shorter OS and RFS(HR=1.73,95%CI:1.32-2.26,P<0.001;HR=2.12,95%CI:1.50-2.99,P<0.001).Subgroup analysis according to the country,sample size,Fib critical value and NOS score showed that the higher level of Fib before operation was related to the shortening of OS in gastric cancer(all P<0.05).  Conclusion   The increase of preoperative Fib can be used as a prognostic index for patients with non metastatic gastric cancer.A higher level of Fib indicates that the prognosis of patients with gastric cancer is poor.

Key words: fibrinogen；gastric cancer, Meta analysis, prognosis