不同年龄段三阴性乳腺癌病人临床病理特征与预后的相关性研究

doi:10.3969/j.issn.1005-6483.2020.03.017

摘要/Abstract

摘要： 目的探讨不同年龄段三阴性乳腺癌病人的临床病理特征与预后的相关性。方法 2005年1月1日～2012年12月31日于我院接受手术的非转移性、三阴性乳腺癌病人365例，按年龄分为老年组（＞65岁）81例，中年组（40～65岁）202例和年轻组（＜40岁）82例。比较3组病人的临床病理特征和治疗方案的选择，采用Kaplan-Meier法计算生存率，并行Logrank检验，Cox风险回归模型进行生存预后分析。结果 3组病人的肿瘤家族史、肿瘤大小、腋窝淋巴结个数和术后病理分期比较，差异无统计学意义（P＞0.05）；3组病人治疗方法（手术方式、是否接受放疗/化疗、化疗药物选择）比较，差异有统计学意义（P＜0.05）；全组中位随访5.5年（4.1～7.9年），年轻组病人5年无局部复发生存和无远处转移生存分别为75.9%和82.3%，显著低于中年组的81.2%、87.0%和老年组的83.3%、88.6%，且组间比较均差异有统计学意义（P＜0.05）；3组病人5年疾病特异性生存分别为79.5%、80.1%和82.4%，差异无统计学意义（P＞0.05）；Cox多因素分析显示手术方式和年龄是影响三阴性乳腺癌预后的独立因素。结论不同年龄段三阴性乳腺癌术后病人的临床病理特征相近，年龄越小，预后越差。

关键词: 三阴性乳腺癌, 病理特征, 病理分期, 多因素分析

Abstract: Objective To explore the relationship between the different aged patients characteristic who diagnosed triple negative breast cancer（TNBC）and the prognosis. Methods The TNBC patients with non-metastatic were enrolled to this study from January 2005 to December 2012，who divided into three groups according to age，elder group（＞65 age）was 81 cases，middle-age group（40～65 age）was 202 cases and young group（＜40 age）was 82 cases respectively.The patients characteristic and the methods of treatment were compared among three groups，meanwhile，the survival was analyzed by Kaplan-Meier and the survival of prognosis was analyzed by Cox risk model. Results The cancer-historic，size of tumor，number of axillary lymph nodes and TNM stages were not significant difference among three groups（P＞0.05）; However，there were significant difference in the methods of treatment among them（P＜0.05）; The median follow-up was 5.5 years（4.1～7.9 years），The 5-years relapse-free survival（RFS），distant relapse free survival（DRFS）were 75.9% and 82.3% in young group，which were significant lower than 81.2%，87.0% of the middle aged group and 83.3%，88.6% of the elderly group（P＜0.05）;The 5-years disease specific survival were 79.5%、80.1% and 82.4% in three groups（P＞0.05）;Cox risk model reveal that ages and methods of operation were independently factors for the prognosis. Conclusion The patients characteristic who diagnosed triple negative breast cancer（TNBC）are not related to ages，however，the youngest patients，the worst prognosis for the TNBC patients.

Key words: triple negative breast cancer, pathological characteristics； pathological staging, multivariate analysis

闾志坚曹玉根李耀. 不同年龄段三阴性乳腺癌病人临床病理特征与预后的相关性研究[J]. 临床外科杂志, 2020, 28(3): 250-253.

LV Zhijian, CAO Yugen, LI Yao.. The relationship between the different aged patients characteristic who diagnosed triple negative breast cancer（TNBC）and the prognosis[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(3): 250-253.

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