Abstract: Objective To investigate the prognostic value of lectin galactoside binding soluble 3 binding protein (LGALS3BP) and growth differentiation factor-15 (GDF-15) in patients with severe acute pancreatitis (SAP).Methods Ninety patients with SAP (SAP group) and 90 patients with mild pancreatitis (MAP) and moderately severe acute pancreatitis (MSAP) (non-SAP group) who attended the First Affiliated Hospital of Xi'an Medical College from January 2021 to January 2024 were foresight selected.The SAP group was separated into a good group(47 cases) and a bad group(43 cases) according to prognosis.Clinical data and relevant testing indicators were collected from the researchers.Compare the levels of serum LGALS3BP and GDF-15 in the SAP group and the non-SAP group; conduct Pearson correlation analysis; perform multivariate Logistic analysis to identify the influencing factors for the prognosis of SAP patients; and use ROC curve analysis to evaluate the value of serum LGALS3BP and GDF-15 in predicting the prognosis of SAP patients.Results Compared with the non-SAP group group,the serum LGALS3BP and GDF-15 levels in the SAP group were greatly increased (65.26ng/ml vs. 118.63ng/ml,1763.46ng/ml vs.2534.83pg/ml,P<0.05).There was a positive correlation between serum LGALS3BP and GDF-15 (r=0.479,P<0.05).The expression levels of LGALS3BP and GDF-15 were lower in SAP patients at 48 h and 72 h after admission than at 24 h after admission,and the expression levels of LGALS3BP and GDF-15 were lower in SAP patients at 72 h after admission than at 48 h after admission (P<0.05).Compared with the poor group,the serum levels of LGALS3BP and GDF-15 in the good group were greatly reduced (135.13ng/ml vs. 103.53ng/ml,2879.63pg/ml vs. 2219.37pg/ml,P<0.05).Compared with the poor group,the C-reactive protein and BISAP scores of SAP patients in the good group were greatly reduced (P<0.05).LGALS3BP and GDF-15 were risk factors affecting the prognosis of SAP (P<0.05).The AUC of serum LGALS3BP for predicting the prognosis of SAP patients was 0.897,with sensitivity and specificity of 81.40% and 93.62%,respectively.The AUC of serum GDF-15 in predicting the prognosis of SAP patients was 0.897,with sensitivity and specificity of 76.74% and 93.62%,respectively.The AUC for predicting the prognostic effect in SAP patients with serum LGALS3BP and GDF-15 combination was 0.974,with sensitivity and specificity of 95.35% and 89.36%,respectively.The Zcombination-LGALS3BP and Zcombination-GDF-15 was 2.194 and 2.227,respectively,with P<0.05.Conclusion Serum LGALS3BP and GDF-15 expression levels are elevated in SAP patients and have a poor prognosis SAP patients have higher serum LGALS3BP and GDF-15 expression levels.Elevated serum LGALS3BP and GDF-15 are detrimental to patient prognosis,and the combination of the two may be used in the future for prognostic assessment of patients with SAP.

Key words: severe acute pancreatitis, lectin galactoside binding soluble 3 binding protein, growth differentiation factor-15, prognosis