Abstract: Objective To investigate the impact of early surgical intervention on mid-term prognosis in patients with Hirschsprung’s disease (HSCR) and to evaluate the risk of Hirschsprung-associated enterocolitis (HAEC).Methods From February 2016 to February 2022,230 children with HSCR who underwent one-stage radical Soave surgery in our hospital were divided into two groups according to the surgical age:the ≤4 months old group (126 cases) and the > 4 months old group (104 cases).The basic conditions of the two groups were compared.The mid-term defecation function of the children was evaluated using the Kelly scoring system.The clinical outcomes were analyzed to assess the risk of HAEC.Results There was no statistically significant difference in postoperative defecation function between the two groups of children (P > 0.05).The incidence of postoperative HAEC was 10.32% in the ≤4 months age group and 21.15% in the > 4 months age group.There was a statistically significant difference between the two groups (P<0.05).The length of intestinal resection,operation time and postoperative hospital stay in the ≤4 months age group were 19.00 cm,83.10 minutes and 6.30 days,respectively;those in the > 4 months age group were 22.83 cm,129.37 minutes and 8.40 days,respectively.There were statistically significant differences between the two groups (P<0.05).Conclusion Early surgical intervention for HSCR has no significant impact on mid-term postoperative bowel function.However,early surgery can reduce the extent of bowel resection,expedite the surgical process,shorten postoperative hospital stay and overall disease course,and effectively decrease the incidence of HAEC.

Key words: hirschsprung’s disease, hirschsprung-associated enterocolitis, early surgical intervention, mid-term prognosis；soave surgery