Abstract: Objective To explore the efficacy of vacuumassisted minimally invasive gyrotomy for benign lesions in the lower quadrant of the breast.Methods From August 2022 to August 2023, 90 patients with benign lesions in the lower quadrant of the breast were treated. According to the different surgical methods, they were divided into two groups: the traditional group included 45 cases, which underwent surgery through the trans-areolar incision; the minimally invasive group included 45 cases, which underwent surgery through the trans-mammary fold incision with vacuum-assisted minimally invasive technique. The surgical-related indicators, inflammatory response indicators, patient satisfaction, and safety were compared between the two groups.Results The operation time [(20.45±6.18) min],intraoperative bleeding [(7.78±2.23) ml],hospital stay [(4.37±1.05) d],scar length [(2.32±0.42) cm] and healing time [(3.46±1.08) d] in the minimally invasive group were significantly better than those in the traditional group [(34.52±9.46)min,(23.16±6.44)ml,(8.72±2.73)d,(19.14±4.18)cm and (7.37±2.16)d] (P<0.05).The levels of IL-6 [(12.14±2.86)ng/L],IL-10 [(14.33±3.74)pg/ml],CRP [(13.85±3.11)mg/L],Cor [(131.27±6.43)nmol/L] and NE [(82.55±8.44) in the minimally invasive group at 3 days after surgery ng/ml were increased and VEGF was decreased [(59.72±7.44)mg/L] than the traditional group [(17.23±3.38)ng/L,(19.62±4.88)pg/ml,(28.36±4.67）mg/L,（196.52±8.84）nmol/L,（117.62±7.14）ng/ml and (88.46±7.89)mg/L](P<0.05).The satisfaction of patients in minimally invasive group (97.78%,44/45) was significantly higher than that in traditional group (82.22%,37/45) (P<0.05).The incidence of adverse events in minimally invasive group (4.44%,2/45) was significantly lower than that in traditional group (22.22%,10/45) (P<0.05).Conclusion Vacuum-assisted minimally invasive rotatory excision can optimize surgical indicators,improve serological indicators,enhance patient satisfaction and treatment safety compared to traditional areola incision surgery.

Key words: vacuum-assisted minimally invasive rotatory excision, benign breast lesions, clinical efficacy