Abstract:

Objective To investigate the expression and clinical significance of microRNA (miR)-539-5p, Caspase activity and apoptosis inhibitory factor 1 (CAAP1) in gastric cancer tissue. Methods The gastric cancer tissue specimens and corresponding adjacent tissues of gastric cancer patients (102 cases) who underwent surgery in Xi ’an Ninth Hospita from January 2018 to December 2019 were collected, and the expression levels of miR-539-5p and CAAP1 in the tissues were detected and compared. The relationship between the expression of miR-539-5p and CAAP1 and clinicopathological parameters and prognosis was explored. The correlation between miR-539-5p and CAAP1 expression was analyzed by Pearson method. Kaplan-Meier method was used to analyze the survival time of gastric cancer patients. Cox regression model was used to analyze the prognostic factors of patients with gastric cancer. Results The expression level of miR-539-5p in gastric cancer tissue lower than that in adjacent tissue, and the expression level of CAAP1 higher than that in adjacent tissue (P<0.05). There was a negative correlation between the expression levels of miR-539-5p and CAAP1 in gastric cancer tissue (P=0.000). Further analysis showed that the expression of miR-539-5p and CAAP1 in gastric cancer tissue was greatly correlated with TNM stage, depth of invasion, lymph node metastasis and tumor size (P<0.05). The 3year survival rate of miR-539-5p high expression group was higher than that of low expression group (P=0.045). The 3year survival rate of CAAP1 high expression group which was lower than low expression group (P=0.015). Cox regression showed that TNM stage, depth of invasion, lymph node metastasis and miR-539-5p and CAAP1 expression were prognostic factors in patients with gastric cancer (P<0.05). Conclusion The decreased expression level of miR-539-5p and increased expression level of CAAP1 in gastric cancer tissues were related to TNM staging, depth of invasion, lymph node metastasis and tumor size, and they are closely related to the prognosis of patients.

Key words: gastric cancer, microRNA-539-5p, Caspase activity and apoptosis inhibitory factor 1