Abstract: Objective To report a case of giant retroperitoneal Castleman disease with tongue ulcers and cutaneous lesions and to improve the understanding of CD. Methods We retrospectively analyzed the clinical data of a case of CD,and discussed the clinical characteristics,diagnosis and treatment of this disease combined with latest literature. Results A 52-year-old woman who found a huge tumor behind the body and tail of pancreas by abdominal CT scan.According to her medical history and physical examination,she was accompanied with symptoms of intractable tongue ulcers and bipedal cutaneous lesions which were healed gradually by an operation of the complete tumor resection.The pathological examination showed that retroperitoneal CD and hyaline vascular subtype. Conclusion CD is a rare multi-clone lymphoproliferative disease without clear causes,which lacks specific clinical manifestations and imaging features,so CD is difficult to diagnosis.For abdominal masses with tongue ulcers and cutaneous lesions,it should be differentiated from CD.

Key words: castleman disease, tongue ulcers, cutaneous lesions, surgical operation