Abstract: Objective To study the repair effect of SIS anal fistula plug on anal fistula after perianal infection. Methods 86 patients with perianal infection combined with high anal fistula in our hospital from June 2018 to June 2020 were selected as the research objects.According to different treatment methods,they were divided into observation group(43 cases) treated with SIS anal fistula plug and control group(43 cases) treated with traditional incision and thread drawing.The clinical efficacy,postoperative pain score,anal incontinence Wexner score,serum cytokine levels and adverse reactions were compared between the two groups. Results The cure rate(86.05%) and total effective rate(93.02%) of the observation group were significantly higher than those of the control group(72.09%,83.72%),and the pain scores of 1,3,7,14 days after operation were significantly lower than those of the control group（ P ＜ 0.05）.There was no significant difference in the preoperative Wexner score of anal incontinence between the observation group and the control group（ P >0.05）,but the Wexner score of anal incontinence in the observation group was significantly lower than that in the control group at one month,three months and six months after operation（ P ＜0.05）.Adverse reactions occurred in both groups,but the total incidence of adverse reactions in the observation group(11.63%) was significantly lower than that in the control group(32.56%)（ P ＜ 0.05）. Conclusion SIS anal fistula plug has a better clinical effect in the repair of high anal fistula after perianal infection,which can effectively reduce the symptoms of postoperative pain and anal incontinence,reduce the incidence of inflammatory reactions and adverse reactions.

Key words: small intestinal submucosa anal fistula plug, perianal infection, anal fistula, repair