JOURNAL OF CLINICAL SURGERY ›› 2021, Vol. 29 ›› Issue (3): 258-260.doi: 10.3969/j.issn.1005-6483.2021.03.016

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Expression of autophagy-related genes in peripheral blood monocytes in patients with breast cancer and its relationship with tumor recurrence

  

  1. Department of General Surgery,the Seventh Affiliated Hospital of Xinjiang Medical University,Xinjiang,Urumqi 830028, China
  • Online:2021-03-20 Published:2021-03-20

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Abstract: Objective  To investigate the expression of Atg5,Atg 9,Beclin 1,ULk1 and Mfn2 in peripheral blood monocytes of breast cancer patients,and its correlation with recurrence.
Method  100 patients with breast cancer treated by radical mastectomy were divided into recurrent group(37 cases),non-recurrence group(63 cases).The expression of Atg5、Atg9、Beclin 1、ULk1 and Mfn2 mRNA were detected by fluorescence quantitative RT-PCR.The relationship between each index and tumor recurrence was analyzed.
Results  The expression of Atg 9、Beclin 1、ULk1 and Mfn2 mRNA of recurrent group were lower than those of the non-recurrence group,and the expression of Atg5 mRNA was higher than that in the non-recurrence group(P=0.007,0.000,0.000,0.000).The clinical stage Ⅲ,histological grade Ⅲ,low expression of Atg9、Beclin 1、ULk1、Mfn2 were risk factors of recurrence.Low expression of Atg5 was protective factor for recurrence(P<0.05).
Conclusion  Low expression of Atg 9、Beclin 1、ULk1 and Mfn2 mRNA in breast cancer is a risk factor for breast cancer recurrence,and low expression of Atg5 gene is a protective factor for recurrence of breast cancer.The detection of its expression is of great significance to evaluate the prognosis of breast cancer after operation.

Key words: breast cancer, autophagy-related gene, mitochondrial fusion protein 2, recurrence

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