Abstract: Objective:The effect of VSD combined with autologous free skin graft on wound healing and VLUQoL score in patients with venous leg ulcers.Methods:62 cases of VLU patients admitted to our hospital from May 2018 to November 2019 were selected as subjects.They were divided into two groups by random number table,31 cases in each group.The control group was treated with simple autologous skin graft.The observation group was treated with VSD combined with autologous free skin graft,and the VSD drainage device was removed 5～7 days after surgery.Wound healing,postoperative infection,dressing times,wound healing time,total hospital stay,and VLUQoL score were analyzed.Results:The good rate of wound healing was 93.55% in the observation group and 70.97% in the control group(P<0.05).The skin infection rate,dressing change times,wound healing time and total hospitalization time of the observation group were 3.23%,(8.70±1.69),(17.32±3.30)d,(13.61±2.20)d,respectively,which were significantly lower than those of the control group[(22.58%,(15.79±2.58),(25.39±4.88)d,(22.13±2.68)d] with significant difference(P<0.05).The total score of vlu QOL,daily life,subjective feelings and local symptoms of the two groups were[(36.87±7.92),(13.56±4.18),(13.01±3.24) and(10.30±2.36) VS(53.05±14.82),(19.72±4.96),(18.55±3.26) and(14.78±2.90),respectively],which were significantly lower than those before operation.Comparison between groups,12 weeks after surgery to observe group VLUQoL scores and the subjective feeling of daily life,the three dimensions,local symptoms score lower than the control group,the difference was statistically significant(P<0.05).Conclusion:VSD combined with autologous free skin graft treatment for patients with venous leg ulcers can promote wound healing,reduce the rate of skin infection,reduce the number of dressing changes,reduce wound healing time,total hospital stay,and improve quality life of VLU QoL score.

Key words: venous leg ulcer, negative pressure closed drainage technique, skin graft, wound healing, quality of life