Abstract: Objective：To observe the efficacy of esophagus jejunum RouxenY anastomosis and jejunal interposition pouch on longterm effect，nutritional status and quality of life in patients undergoing gastric cancer surgery.Methods：65 patients with gastric cancer undergoing radical gastrectomy were retrospectively analyzed.According to their surgical treatment，they were divided into JIP group（29 cases）and RouxenY group（36 cases）.The operation time，postoperative hospitalization time，longterm complications，nutritional status and the quality of life were compared between the two groups.Results：There were no significant differences in the operation time [（124.36±13.47）min vs（122.09±14.28）min]，postoperative hospitalization time [（14.98±3.65）d vs（15.38±3.72）d]，the incidence of reflux esophagitis [17.24%（5/29）vs 16.67%（6/36）] and the incidence of diarrhea [6.90%（2/29）vs 8.33%（3/36）] between the two groups（P>0.05），while the incidence of dumping syndrome [10.34%（3/29）] and RSS syndrome [13.79%（4/29）] after 6 months in the JIP group was significantly lower than that in the RouxenY group [44.44%（16/36），30.56%（11/36）] （P<0.05）.The two groups showed significant differences in the hemoglobin growth [（18.56±3.08）g/L vs（12.42±2.16）g/L]，albumin growth [（13.74±2.36）g/L vs（8.01±2.17）g/L]，weigh growth [（4.69±2.87）kg vs（2.27±1.35）kg] and prognostic nutrition index growth [（15.33±4.07）vs（5.87±1.82）].The total quality of life in JIP group was better than that in RouxenY group [（87.69±11.12）vs（73.62±10.77）]（P<0.05）.〖Conclusion：Compared with esophagus jejunum RouxenY anastomosis after total gastrectomy，the patients with stomach cancer who received proximal subtotal gastrectomy plus jejunal interposition surgery show less longterm complications，better nutritional status and quality of life.

Key words: RouxenY anastomosis, jejunal interposition pouch, nutritional status, quality of life