JOURNAL OF CLINICAL SURGERY ›› 2020, Vol. 28 ›› Issue (1): 54-57.doi: 10.3969/j.issn.1005-6483.2020.01.016

Previous Articles     Next Articles

Effect of aquaporin AQP4 in invasion and metastasis of breast cancer cells

  

  1. Department of Breast Surgery，Inner Mongolia people's Hospital，Hohhot 010017，China
  • Online:2020-01-20 Published:2020-01-20

PDF (PC)

1887

PDF (Mobile)

893

Abstract: Objective To investigate the mechanism of aquaporin 4（AQP4）in the development of breast cancer.Methods The expression of aquaporin 4 in the T47D and MCF-7 cell lines of breast cancer cells was downregulated by siRNA interference，and the effect of this down regulation on the invasion and metastasis of breast cancer cells was detected.Results Decreased expression of AQP4 inhibits invasion and metastasis of breast cancer cells.Conclusion The expression level of AQP4 is correlated with the development of breast cancer，and it can further develop into a new target.

Key words: aquaporin 4, small interferes RNA, invasion, metastasis

[1] . Effect on tumor cells with it’s microenvironment switched by sodium hydrogen exchanger isoform [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(9): 825-827.
[2] . Lymph Node Metastasis in thymic malignancies [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(7): 622-625.
[3] . Preoperative influencing factors analysis of thoracic midupper esophageal carcinoma with cervical lymph node Metastasis  [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(7): 566-569.
[4] . Snail mediating the migration and invasion in esophageal squamous cell carcinoma by regulating Ecadherin [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(7): 562-565.
[5] . Application of hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis metastasis of gastrointestinal tumor [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(5): 443-445.
[6] . Study of overexpression of Fbxw7 promotes mTOR degradation and inhibits migration of gastric cancer cells [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(5): 379-382.
[7] . The application value and prospect of cell inactivation and intraperitoneal thermal perfusion chemotherapy in patient with colorectal cancer with peritoneal metastasis [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(11): 1011-1013.
[8] . Survival and Risk factors of treatment failure in pT thoracic esophageal squamous cell carcinoma after radical resection [J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(9): 657-661.
[9] ZHANG Yi, MA Dandan, ZHANG Zhaolin, et al. The effect and mechanism of miR31 on the metastasis and invasion of colon cancer [J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(10): 747-750.
[10] JI Le, LIU Tao, BAI Lang, et al. Effect of laparoscopic D2 radical distal gastrectomy on expression of peritoneal lavage levels of CEA，DDC and serum levels of HIF1α，MACC1 in elderly patients with advanced gastric cancer [J]. JOURNAL OF CLINICAL SURGERY, 2018, 26(10): 739-743.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . Surgical treatment of eightysix child patients with anomalous left coronary artery from the pulmonary artery [J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(5): 416 -418 .
[2] CHEN Lin, DONG Hanhua, CHEN Qi, et al. Standardized procedure for pancreaticoduodenectomy-Tongji university experience[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 5 -7 .
[3] ZHANG Tao, SUN Bei. Clinical practice guidelines for NCCN pancreatic cancer(V2 edition) updated in 2019[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 8 -11 .
[4] TANG Jianxiong, LI Hangyu. Interpretation of Chinese expert consensus on the diagnosis and treatment of inguinalhernia in the elderly (2019 edition)[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 12 -15 .
[5] WANG Wenqiang, ZHANG Erlei, XIANG Shuai, et al. Pulse-first continuous blockade technique: a new strategy for the resection of giant hepatic hemangioma[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 16 -18 .
[6] JIA Weidong, LIU Wenbin. Interpretation of multidisciplinary expert consensus on diagnosis and treatment of hepatic hemangioma (2019 edition)[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 19 -22 .
[7] CHEN Zhiyu, BIE Ping. Expert consensus on the application of choledochostomy in hepatolithiasis (2019 edition)[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 23 -26 .
[8] LIN Jinna, LIU Qiang. Clinical practice guidelines of NCCN breast cancer updated in 2019: new advances in local treatment of breast cancer[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 27 -30 .
[9] WEI Wei, LI Peng. Interpretation of the first edition of NCCN guidelines for the treatment of thyroid malignancy in 2019#br#[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 31 -34 .
[10] ZHANG Renquan, KANG Ning, NING Zhenghao. Interpretation of recommendations from Chinese clinical experts on robot-assisted esophagectomy (2019 edition)#br#[J]. JOURNAL OF CLINICAL SURGERY, 2020, 28(1): 35 -37 .
Copyright © JOURNAL OF CLINICAL SURGERY, All Rights Reserved.
Tel: 027-87893476　E-mail: whlcwk@126.com
Powered by Beijing Magtech Co. Ltd