Abstract: Objective：To investigate the high risk factors of poor wound healing after cardiovascular surgery，and to analyze these high risk factors and their countermeasures.Methods：The medical records of patients undergoing cardiovascular surgery from April 2010 to April 2018 were analyzed.86 patients with poor wound healing after operation were selected as treatment group and 172 patients with good wound healing as control group.The data of perioperative period were compared and analyzed between the two groups.Results：The two groups of patients in over 70 years old，female patients，combined surgery，preoperative skin preparation，absorbable suture use，the utilization rate of surgical membrane，the saline irrigation incision before suture have no significant difference（P>0.05）.There were significant differences in incidence of hypoproteinemia in the two groups，ejection fraction<40 after operation，emergency surgery，unplanned reoperation，the use of internal mammary artery，pericardial effusion，temperature<34℃，operation time>4h and cardiopulmonary bypass time>2h（P<0.05）.〖WTHZ〗Conclusion：Gender，age>70years old，combined operation，skin preparation before operation are not significantly related to wound healing，but malnutrition，organ dysfunction，operation timing，incision local environment are the high risk factors of incision healing.

Key words: incision infection, poor healing, vacuum sealing drainage, cardiac surgery