临床外科杂志 ›› 2022, Vol. 30 ›› Issue (3): 244-247.doi: 10.3969/j.issn.1005-6483.2022.03.013

• 论著 • 上一篇    下一篇

Gankyrin蛋白在乳腺浸润性导管癌和癌前病变组织中表达的意义

  

  1. 作者单位:100050 首都医科大学附属北京天坛医院乳腺外科(曲更宝、王峰、朱强),中医科(王宝凯)
  • 收稿日期:2021-08-17 接受日期:2021-08-17 出版日期:2022-03-20 发布日期:2022-03-20

The expression significance of Gankyrin protein in breast invasive ductal carcinoma and precancerous lesions

  • Received:2021-08-17 Accepted:2021-08-17 Online:2022-03-20 Published:2022-03-20

摘要: 目的 研究癌症基因Gankyrin在乳腺浸润性导管癌(invasive ductal carcinoma,IDC)和癌前病变组织中表达的意义。 方法 2016年1月~2018年6月间手术切除的IDC和癌前病变组织石蜡标本105例,其中IDC组织石蜡标本65例,癌前病变组织石蜡标本40例,另取同期手术切除的非肿瘤病变的正常乳腺组织石蜡标本25例作为对照。比较不同组织病理标本中Gankyrin表达的差异,分析IDC组织病理标本中Gankyrin表达与疾病特点及预后的关系。 结果 Gankyrin在IDC中的表达高于癌前病变及正常乳腺组织,差异有统计学意义( P <0.05),Gankyrin在癌前病变中的表达高于正常乳腺组织,差异有统计学意义( P <0.05)。在IDC病人中,有淋巴结转移者Gankyrin表达阳性率(94.1%)高于无淋巴结转移者(67.7%),差异有统计学意义( P <0.05);有脉管内瘤栓者Gankyrin表达阳性率(91.7%)高于无脉管内瘤栓者(69.0%),差异有统计学意义( P < 0.05)。Gankyrin阳性表达者3年无病生存期(progression-free survival,DFS)为24.49%,阴性表达者为3年DFS为60.00%,Gankyrin表达阳性病人与阴性表达者3年DFS曲线比较差异有统计学意义( P <0.05)。Cox回归分析显示,临床分期、分化程度、淋巴结转移情况、Gankyrin阳性表达是影响DFS的独立预后因素( P <0.05)。 结论 癌症基因Gankyrin在IDC、癌前病变组织中多为高表达,Gankyrin表达与IDC疾病的预后有关。

关键词: 乳腺肿瘤, 浸润性导管癌, 癌前病变, Gankyrin表达

Abstract: Objective To study the expression significance of cancer gene Gankyrin in invasive ductal carcinoma(IDC) and precancerous lesions of the breast. Methods A total of 105 cases of IDC and precancerous tissue paraffin specimens resected during January 2016 to June 2018 were selected as research objects,including 65 cases of IDC tissue paraffin specimens and 40 cases of precancerous tissue paraffin specimens,and another 25 cases of normal breast tissue paraffin specimens with nontumor lesions resected during the same period were taken as controls.Compared the expression of Gankyrin in different histopathological specimens,and explore the relationship between Gankyrin expression in IDC histopathological specimens and disease characteristics and patient prognosis. Results The expression of Gankyrin in IDC was significantly higher than that in precancerous lesions and normal breast tissue( P <0.05),and the expression of Gankyrin in precancerous lesions was significantly higher than that in normal breast tissue( P <0.05).Among IDC patients,the positive rate of Gankyrin expression in patients with lymph node metastasis was 94.1%,which was significantly higher than that of patients without lymph node metastasis(67.7%)( P <0.05);the positive rate of Gankyrin expression in patients with intravascular tumor thrombus was 91.7%,significantly higher than those without intravascular tumor thrombus( 69.0 %)( P <0.05).The 3-year DFS of Gankyrin positive expression was 24.49%,and the 3-year DFS of negative expression was 60.00%.There was a statistically significant difference in the 3-year DFS curve between Gankyrin positive expression and negative expression( P <0.05).Cox regression analysis showed that clinical stage,degree of differentiation,lymph node metastasis,and Gankyrin positive expression were independent prognostic factors affecting progression-free survival(DFS)( P <0.05). Conclusion The cancer gene Gankyrin is highly expressed in IDC and precancerous tissues.Gankyrin expression is related to the prognosis of IDC disease.

Key words: breast neoplasms, invasive ductal carcinoma, precancerous lesions, Gankyrin expression

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