浸润性导管癌合并导管原位癌的临床病理特点分析

doi:10.3969/j.issn.1005-6483.2021.11.015

摘要/Abstract

摘要： 目的分析浸润性导管癌合并导管原位癌(IDC+DCIS)与单纯浸润性导管癌(IDC)的临床病理特点。
方法 2016~2020年我科收治的乳腺癌病人335例，其中IDC+DCIS组123例，IDC组 212例。采用SPSS 23.0软件进行统计分析，比较两组间肿块大小，淋巴结分期以及雌激素受体、孕激素受体、人类表皮生长因子受体2（HER-2）、细胞增殖核抗原、细胞角蛋白5/6（CK5/6）等分子指标的表达差异。
结果 IDC+DCIS组的HER-2阳性率明显高于IDC组(40.7% vs 25%，P=0.003)，而CK5/6的阳性率显著低于IDC组(10.4% vs 42.6%，P=0.00)。此外IDC组有更高的三阴型乳腺癌比率(23.3% vs 9.8%，P=0.02)。
结论 IDC+DCIS与IDC比较，表现出不同的免疫组化表型。这种表型的差异是否预示着两种癌通过不同的途径浸润，值得进一步探讨。

关键词: , 乳腺肿瘤；原位乳腺癌；免疫组织化学

Abstract: Objective Analyze the clinicopathological features of invasive ductal carcinoma with ductal carcinoma in situ(IDC+DCIS) and invasive ductal carcinoma(IDC).
Methods 335 breast cancer patients treated in the Department of Thyroid and Breast Surgery,Maternal and Child Hospital of Hubei Province from 2016 to 2020 were adopted,including 123 patients in the IDC+DCI group and 212 patients in the IDC group.SPSS 23.0 software was used for statistical analysis to compare the tumor size,lymph node stage,and the expression of ER,PR,HER-2,Ki-67%,CK5/6 and other molecular indicators between the two groups.
Results The expression of HER-2 in the IDC+DCIS group was higher than that in the IDC group(40.7% vs 25%,P=0.003),while the positive rate of CK5/6 was significantly lower than that in the IDC group(10.4% vs 42.6%,P=0.00).In addition,the IDC group had a higher rate of triple negative breast cancer(23.3% vs 9.8%,P=0.02).
Conclusion Compared with invasive carcinoma,invasive ductal carcinoma with carcinoma in situ shows different immunohistochemical phenotype.Whether this difference in phenotype indicates that the two cancers infiltrate through different pathways is worthy of further research.

Key words: breast neoplasms, breast carcinoma in situ, immunohistochemistry

郑媛陈波. 浸润性导管癌合并导管原位癌的临床病理特点分析[J]. 临床外科杂志, 2021, 29(11): 1047-1049.

ZHENG Yuan, CHEN Bo.. Retrospective analysis of clinicopathological features of invasive ductal carcinoma with ductal carcinoma in situ[J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(11): 1047-1049.

参考文献

相关文章 15

[1]	柳硕岩, 何皓, 王枫. 胸段食管鳞癌日本食管协会和国际抗癌联盟分期的比较和思考[J]. 临床外科杂志, 2021, 29(8): 707-711.
[2]	吴文博, 张霄鹏, 薛文飞等. 胸部CT平扫三维重建与增强扫描〖JP2〗三维重建技术在解剖性肺段切除中〖JP〗的应用分析[J]. 临床外科杂志, 2021, 29(8): 730-734.
[3]	于航王永祥周岳来董辉徐晓航胡乐. 合并同侧股骨干骨折的Hoffa骨折的临床特点及疗效分析[J]. 临床外科杂志, 2021, 29(11): 1086-1088.
[4]	张清河, 宋康颉, 潘绪科. 胰腺损伤六例诊治体会[J]. 临床外科杂志, 2020, 28(6): 562-563.
[5]	姚建锋, 田利飞, 张晓龙等. 基于单中心的不同手术组人员成人腹股沟疝修补术现状调查[J]. 临床外科杂志, 2020, 28(6): 572-574.
[6]	吴琼, 范洲, 丁召等. 顺蠕动侧侧肠吻合和功能性端端肠吻合在Crohn's病消化道重建中的应用[J]. 临床外科杂志, 2020, 28(5): 447-450.
[7]	王松, 谢秋萍, 王平. 全腔镜甲状腺手术热点与难点[J]. 临床外科杂志, 2020, 28(3): 224-226.
[8]	孙先龙, 赵礼金, 蒋继昌. 胆总管神经内分泌肿瘤一例[J]. 临床外科杂志, 2020, 28(2): 199-200.
[9]	沈辉, 张扬, 陈海泉. ⅢA期非小细胞肺癌以外科为基础的多学科治疗[J]. 临床外科杂志, 2020, 28(11): 1003-1006.
[10]	付亮, 赵金龙, 倪寅凯等. 经股静脉单纯食道超声引导下房间隔缺损封堵的近中期疗效[J]. 临床外科杂志, 2020, 28(11): 1016-14018.
[11]	李欣龙, 顾立虎, 祝和攀, 潘军海, 陈玉萍. 加速康复外科理念在腹腔镜胃癌根治术中的应用[J]. 临床外科杂志, 2019, 27(5): 404-407.
[12]	方坤, 罗明尧, 赵嘉伟, 薛云飞, 舒畅. 3D导航技术在主动脉腔内修复术中的应用[J]. 临床外科杂志, 2019, 27(11): 938-942.
[13]	吴洋, 窦娟, 乔芊芊等. 超声引导竖脊肌平面阻滞对多发肋骨骨折术后镇痛效果的影响[J]. 临床外科杂志, 2019, 27(11): 984-986.
[14]	王国义梁剑峰田锦林鲍峰. 内镜直视与X线透视下支架置入术治疗晚期食管贲门癌临床疗效比较[J]. 临床外科杂志, 2018, 26(9): 679-682.
[15]	马跃峰邢鑫马震川孔冉冉孙良璋乔哲李少民. 术中肋间神经阻滞联合术后静脉使用镇痛泵对开胸术后镇痛效果的观察[J]. 临床外科杂志, 2018, 26(9): 686-688.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed