关键词: 肾移植, 人细小病毒B19, 贫血, 静脉注射免疫球蛋白

Abstract: Objective To investigate the clinical features,auxiliary examination，diagnosis and treatment  of pure red cell aplasia (PRCA) caused by human parvovirus B19 (HPV-B19) infection after kidney transplantation,andto guide the treatment of diseases like this in future.
Methods The clinical treatment and outcome of three patients with PRCA caused by HPV-B19 infection after kidney transplantation between May 2016 and February 2019 were retrospectively investigated.
Results The three patients showed obvious anemia symptoms,lacking other clinical symptoms of viral infection.Two patients accept treatment of adjusting the dose of immunosuppressant;All three patients accept symptomatic treatment and 1 to 2 weeks of intravenous immunoglobulin after positive diagnosis,all of them showed clinical remission.One case occurred recrudescence with HPV-B19 DNA(+）and improved after the same treatment.All patients have blessing performance by now.No serious adverse reactions occurred and all patients had stable graft function.No accidents such as organ failure or immunological rejection showed at all.
Conclusion The main clinical manifestations of PRCA caused by HPV-B19 infection after kidney transplantation are anemia symptoms,blood examination,bone marrow cytology and immunological examination can diagnose HPV-B19 infection.Adjusting immunosuppressant and IVIG can be the safe and effective treatment.

Key words: kidney transplantation, Human parvovirus B19, anemia, intravenous immunoglobulin