临床外科杂志 ›› 2018, Vol. 26 ›› Issue (12): 910-912.doi: 10.3969/j.issn.10056483.2018.12.006

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移植肾功能恢复延迟伴发横纹肌溶解症一例

  

  1. 华中科技大学同济医学院附属同济医院器官移植研究所/器官移植教育部重点实验室/国家卫生健康委员会器官移植重点实验室/中国医学科学院器官移植重点实验室
  • 出版日期:2018-12-20 发布日期:2018-12-20

Necrotizing fasciitis after renal transplantation:2 cases report

  • Online:2018-12-20 Published:2018-12-20

摘要: 目的 分析他汀类药物导致肾移植受者横纹肌溶解症的诊治方法。方法 1例肾移植受者应用阿托伐他汀和环孢素A导致的横纹肌溶解症。该例病人因高脂血症已口服阿托伐他汀近2年,因患糖尿病,肾移植术后采用以环孢素A为基础的药物预防排斥反应,同时继续阿托伐他汀治疗。结果 术后出现移植肾功能恢复延迟,第22天肾功能恢复,第29天诊断为横纹肌溶解症,第33天出现急性肾损伤,第75天移植肾受者肾功能恢复,症状缓解,随访至2018年9月29日,血肌酐稳定在80μmol/L左右。结论 使用环孢素A预防排斥反应的肾移植受者,在治疗高脂血症时,若合并使用经CYP3A4代谢的他汀类药物,应当小剂量开始服用,同时注意潜在的肌肉毒性。

关键词: 肾移植, 〓 他汀类药物, 〓 横纹肌溶解症, 〓 急性肾损伤

Abstract: Objective〖WTBZ〗〓To investigate diagnosis and treatment methods of the statininduced rhabdomyolysis in renal transplant recipients.〖WTHZ〗Methods〖WTBZ〗〓A retrospective study was performed on the clinical date of a case of atorvastatininduced rhabdomyolysis and acute renal failure triggered by addition of cyclosporine A(CsA)to a kidney transplant recipient.Given his diabetes,the recipient received CsAcontaining immunosuppressive regimens,and he had been continually treated with atorvastatin(20 mg/d)owing to hyperlipidemia for the preceding 2 years.〖WTHZ〗Results〖WTBZ〗〓The patient got a delayed graft function until the 22nd day after the operation.Then the patient developed severe rhabdomyolysis on the 29th day after the surgery,followed by acute kidney failure in 33 days.Finally,he showed gradual recovery in renal function and overall clinical status on the 75th day after the surgery.The serum creatinine remained stable at about 80 μmol/L at the time of the followup to March 29,2018.〖WTHZ〗Conclusion〖WTBZ〗〓It is advisable to start with small dosage of lipidlowering agent and pay more attention to the possible muscle toxicity when the CsAtreated renal transplant recipient took statins metabolized by CYP3A4 for hyperlipidemia.

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