关键词: 短肠综合征； 慢性肠衰竭； 综合管理； 营养支持治疗

Abstract: Short bowel syndrome(SBS) is a severe clinical condition resulting from extensive intestinal resection,leading to a significant reduction in functional small bowel length(typically≤200 cm).The core pathophysiological change is a severe insufficiency of the effective absorptive surface area,which subsequently causes malabsorption of macronutrients and micronutrients,as well as fluid and electrolyte imbalances.Primary clinical manifestations include refractory diarrhea,progressive malnutrition,and specific nutrient deficiencies.The management of SBS requires a multidisciplinary team to implement personalized,comprehensive treatment strategies.These strategies encompass stepwise nutritional support therapy,meticulous fluid and electrolyte management,targeted pharmacological interventions,and for some patients,the use of glucagon-like peptide（GLP）-2 analogs to promote intestinal adaptation.Surgical treatments,such as intestinal reconstruction or transplantation,are reserved for specific cases.Long-term management should focus on monitoring and preventing complications.The ultimate goals are to achieve intestinal autonomy and improve the patient's quality of life.

Key words: short bowel syndrome; chronic intestinal failure; comprehensive management; nutritional support therapy