术前淋巴细胞、C反应蛋白及其比值对结直肠癌腹腔镜根治术后并发症的预测价值

doi:10.3969/j.issn.1005-6483.20250271

摘要/Abstract

摘要： 目的探讨术前淋巴细胞、C反应蛋白（CRP）及其比值（LCR）对结直肠癌腹腔镜根治术后并发症的预测价值。方法2021年10月~2024年10月行腹腔镜根治术的结直肠癌病人120例，使用Clavien-Dindo分级评估术后并发症发生情况，将病人分为并发症组与对照组。单因素及多因素Logistic回归分析术后并发症发生风险的影响因素。受试者工作特征（ROC）曲线检测影响因素对术后并发症的预测价值。结果术后30天内发生Clavien-Dindo分级≥Ⅱ级的病人51例；并发症组淋巴细胞及LCR比值低于对照组，CRP水平高于对照组，差异有统计学意义（P＜0.05）；单因素分析结果显示，并发症组LCR低于对照组，年龄、手术时间高于、长于对照组，糖尿病及高血压患病人数多于对照组，差异有统计学意义（P＜0.05）；多因素Logistic回归分析，LCR、年龄、糖尿病、手术时间是影响术后并发症的独立危险因素（P＜0.05）；ROC曲线分析表明，术前LCR指数、年龄、糖尿病、高血压、手术时间的AUC分别为0.934、0.645、0.604、0.631、0.821，敏感性分别为92.75%、52.94%、41.18%、39.22%、80.39%，特异性分别为88.24%、66.67%、79.71%、86.96%、75.36%。结论LCR的降低与结直肠癌腹腔镜根治术病人术后并发症的发生有关。

关键词: 结直肠癌, 腹腔镜根治术, 淋巴细胞, C反应蛋白

Abstract: Objective To explore the predictive value of preoperative lymphocyte,C-reactive protein (CRP) and their ratio (LCR) on complications after laparoscopic radical resection of colorectal cancer.Methods The clinical data of 120 patients with colorectal cancer who received laparoscopic radical resection from October 2021 to October 2024 were retrospectively analyzed.Clavien-Dindo grading was used to evaluate the occurrence of postoperative complications.The patients were divided into complication group and control group.Multivariate logistic regression analysis of factors influencing the risk of postoperative complications.The predictive value of receiver operating characteristic (ROC) curve detection of influencing factors for postoperative complications.Results According to the follow-up results,there were 51 patients with Clavien-Dindo grade≥ Ⅱ within 30 days after surgery.The lymphocyte and LCR in complication group were lower than those in control group (P<0.05) while the CRP level was higher than that in control group (P<0.05).The results of univariate analysis showed that the LCR of the complication group was lower than that of the control group (P<0.05),the age and operation time of the complication group were higher than that of the control group (P<0.05),and the number of patients with diabetes and hypertension in the complication group was more than that in the control group (P<0.05).Multivariate logistic regression analysis,LCR、Age,diabetes and operation time were independent risk factors for postoperative complications (P<0.05).ROC curve analysis showed that the AUC of preoperative LCR index,age,diabetes,hypertension,and operation time were 0.934,0.645,0.604,0.631,0.821,respectively,the sensitivity was 92.75%,52.94%,41.18%,39.22%,80.39%,and the specificity was 88.24%,66.67%,79.71%,86.96%,75.36%,respectively.Conclusion The decrease of LCR is related to the occurrence of postoperative complications in patients undergoing laparoscopic radical resection of colorectal cancer.

Key words: colorectal cancer, laparoscopic radical resection, lymphocyte, C-reactive protein

刘杨旸, 刘少帅, 黄昱. 术前淋巴细胞、C反应蛋白及其比值对结直肠癌腹腔镜根治术后并发症的预测价值[J]. 临床外科杂志, 2026, 34(1): 74-77.

LIU Yangyang, LIU Shaoshuai, HUANG Yu. Predictive value of preoperative lymphocyte,C-reactive protein and their ratio on complications after laparoscopic radical resection of colorectal cancer[J]. JOURNAL OF CLINICAL SURGERY, 2026, 34(1): 74-77.

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