关键词: 甲状腺乳头状癌, 高迁移率族蛋白2, ADAMTS8, 临床病理参数, 预后

Abstract: Objective  To investigate the relationship between the levels of high mobility group protein A2(HMGA2) and a disintegrin and metalloproteinase with thrombospondin motifs 8(ADAMTS8) in papillary thyroid carcinoma(PTC) tissue with clinical pathological parameters and prognosis.Methods Cancer and adjacent tissues of 128 PTC patients who underwent thyroidectomy in our hospital from December 2018 to December 2020 were collected,and clinical and pathological characteristics of the patients were collected.Immunohistochemical staining was applied to detect the expression levels of HMGA2 and ADAMTS8 proteins in tissues,and their relationship with clinical pathological parameters was analyzed.Kaplan-Meier curve was applied to analyze the relationship between HMGA2 and ADAMTS8 expression and the prognosis of PTC patients.Multivariate Cox regression was applied to analyze the impacts of HMGA2 and ADAMTS8 expression on the prognosis of PTC patients.Results The positive expression rates of HMGA2 protein in PTC tissues and adjacent tissues were 64.84% and 32.03%,respectively,and the positive expression rates of ADAMTS8 procoprotein were 61.72% and 34.38%,respectively.There was a statistically significant difference between the two groups (P < 0.001).The expression levels of HMGA2 and ADAMTS8 proteins in PTC tissue were related to vascular invasion,TNM staging,lymph node metastasis,and differentiation degree(P<0.05).The 3-year survival rate of HMGA2 and ADAMTS8 positive expression patients was lower than that of negative expression patients(χ2=4.807,4.236,P<0.05).Positive expression of HMGA2(HR=1.752,95%CI=1.129~2.718) and positive expression of ADAMTS8(HR=1.497,95%CI=1.113~2.013) were risk factors for mortality in PTC patients(P<0.05).Conclusion The positive expression rates of HMGA2 and ADAMTS8 proteins are relatively high in PTC tissues,and their expression levels are related to clinical pathological parameters and prognosis,which has certain clinical value.

Key words: thyroid papillary carcinoma, high mobility group protein A2, a disintegrin and metalloproteinase with thrombospondin motifs 8, clinical pathological parameters, prognosis