临床外科杂志 ›› 2021, Vol. 29 ›› Issue (7): 635-638.doi: 10.3969/j.issn.1005-6483.2021.07.013

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轻型颅脑损伤病人血清高迁移率族蛋白B1、泛素C末端水解酶L1和神经元特异性烯醇化酶水平变化及与预后的相关性分析

  

  1. 435000 湖北黄石,鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)神经外科(谢元润、马迎辉、叶继业、陈超);华中科技大学附属同济医院神经内科(何畅)
  • 出版日期:2021-07-20 发布日期:2021-07-20
  • 通讯作者: 马迎辉,Email:mayinghui12345@163.com
  • 基金资助:
    湖北省自然科学基金资助项目(2017CFB392)

Changes of serum HMGB1,UCH-L1 and NSE levels in patients with mild head injury and their correlation with prognosis

  1. Department of  Neurosurgery,Huangshi Central Hospital,Affiliated Hospital of Hubei Polytechnic University,Edong Healthcare Group,Hubei,Huangshi 435000,China
  • Online:2021-07-20 Published:2021-07-20

摘要: 目的  分析轻型颅脑损伤(MHI)病人血清高迁移率族蛋白B1(HMGB1)、泛素C末端水解酶L1(UCH-L1)和神经元特异性烯醇化酶(NSE)水平变化及与预后的相关性。
方法  2017年1月~2019年1月收治的84例MHI病人为MHI组,根据格拉斯哥预后量表(GOS)分为预后不良组(23例)和预后良好组(61例),另选取同时期57例来我院体检健康者为对照组。对比各组血清HMGB1、UCH-L1、NSE水平。多因素Logistic回归分析MHI病人预后不良影响因素,ROC分析血清HMGB1、UCH-L1、NSE水平对MHI病人不良预后的预测价值。
结果  MHI组血清HMGB1、UCH-L1、NSE水平高于对照组,差异有统计学意义(P<0.05)。预后不良组复合损伤、并发症比例和血清HMGB1、UCH-L1、NSE水平高于预后良好组,差异有统计学意义(P<0.05)。复合损伤、HMGB1、UCH-L1、NSE为MHI病人预后不良独立影响因素(P<0.05)。ROC曲线显示,HMGB1+UCH-L1+NSE预测MHI不良预后的AUC明显大于HMGB1、UCH-L1、NSE单独预测。
结论  MHI病人血清HMGB1、UCH-L1、NSE水平明显提升,与预后密切相关,联合检测可提升MHI不良预后预测价值。

关键词: 轻型颅脑损伤, 高迁移率族蛋白B1, 泛素C末端水解酶L1, 神经元特异性烯醇化酶, 预后

Abstract: Objective To investigate the changes of serum high mobility group protein B1(HMGB1),ubiquitin C-terminal hydrolase L1(UCH-L1) and neuron-specific enolase(NSE) levels in patients with mild head injury(MHI) and correlation with prognosis.
Methods A total of 84 MHI patients admitted to our hospital(January 2017 to January 2019) were selected as the MHI group,according to the Glasgow Outcome Scale(GOS),it is divided into a poor prognosis group(n=23) and a good prognosis group(n=61),in addition,57 healthy patients who came to our hospital for physical examination during the same period were selected as the control group.Compare the serum HMGB1,UCH-L1,and NSE levels in each group,Multivariate Logistics regression analysis of factors affecting the prognosis of MHI patients,ROC analyzes the predictive value of serum HMGB1,UCH-L1,and NSE levels for the poor prognosis of MHI patients.
Results The levels of serum HMGB1,UCH-L1,and NSE in the MHI group were significantly higher than those in the control group(P<0.05).The proportion of complex injuries,complications and serum HMGB1,UCH-L1 and NSE levels in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).Compound damage,HMGB1,UCH-L1,NSE were independent factors influencing the poor prognosis of MHI patients(P<0.05).The ROC curve shows that the AUC of HMGB1+UCH-L1+NSE predicting the poor prognosis of MHI is significantly greater than that of HMGB1,UCH-L1,NSE were predicted separately.
Conclusion The serum levels of HMGB1, UCH-L1 and NSE in MHI patients were significantly increased, which were closely related to the prognosis. Combined detection could improve the prognostic value of MHI.

Key words: mild head injury, high mobility group protein B1, ubiquitin C-terminal hydrolase L1, neuron-specific enolase, prognosis

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