Abstract: Objective To investigate the compliance of hormone receptor-positive breast cancer patients with prolonged endocrine therapy and analyze its influencing factors.Methods This study was a retrospective cohort study.A total of 347 patients with breast cancer who received prolonged endocrine therapy in our hospital from June 2017 to March 2023 were selected. Relevant data of the patients were collected and they were divided into two groups according to whether they adhered to prolonged endocrine therapy: the compliance group and the non-compliance group.Using the χ² test to analyze the impact of patients' disease-related data on prolonging compliance with endocrine therapy.Use Logistic regression to analyze its influencing factors.Results Among 347 breast cancer patients who received extended endocrine therapy, during the median follow-up of 28 months (ranging from 12 to 60 months), 319 patients (91.9%) adhered to extended endocrine therapy (compliance group), and their treatment compliance was acceptable. Twenty-eight cases (8.1%) of patients did not adhere to prolonged endocrine therapy (non-compliance group).Multivariate analysis showed that the independent factors Influencing the compliance of breast cancer patients with prolonged endocrine therapy were comorbidities and radiotherapy(P＜0.05).Conclusion Based on the characteristics of influencing factors, behavioral interventions such as increasing follow-up frequency and strengthening health education content can be implemented for some patients without comorbidities and those who have not received radiation therapy,and to improve treatment compliance.

Key words: breast cancer, extended endocrine therapy, treatment adherence, influencing factors