Abstract: Objective In order to investigate the etiology and drug resistance of vancomycin resistant enterococci after liver transplantation.
Methods We retrospectively analyzed the clinical data of 524 consecutive patients who underwent liver transplantation in Beijing Chaoyang Hospital in January 2015-2019 in December.Incidence rate and etiology of vancomycin resistant enterococci infection after operation were analyzed.Distribution and drug resistance.
Results 109 of the 524 patients underwent abdominal infection after operation,the incidence rate was 20.80%(109/524).Enterococcus infection was 46 cases,all enterococcus faecium,enterococcal infection rate was 8.78%(46/524),enterococcal infection accounted for 42.2%(46/109) of the patients with abdominal infection,accounting for 64.79%(46/71) of gram positive cocci infection,15 cases of vancomycin resistant hair coloring and 15 vancomycin resistance rate of 32.61%(15/46),and drug sensitivity test showed 
vancomycin resistant enterococcus was completely resistant to penicillin, ampicillin, ciprofloxacin, levofloxacin and erythromycin antibiotics;it was also widely resistant to tetracycline, streptomycin, gentamicin and other antibiotics;and the drug resistance rates were 71.43%(15/21),85.71%(18/21),71.43%(15/21),38.10%(8/21) to teicoplanin,and resistant strains to linezolid,the drug resistance rate was 9.52%(2/21).Tecycline is the most sensitive and no resistant bacteria have been detected.
Conclusion Vancomycin resistant Enterococcus is one of the common pathogens in liver transplantation patients.Conventional prophylactic antibiotics are ineffective in the treatment of vancomycin resistant enterococci,and tigecycline and linezolid can be the first choice for the treatment.

Key words: liver transplantation, vancomycin resistant enterococcus, drug resistance