Abstract: Objective：The pathogenic bacteria and drug resistance of postoperative intracranial infection patients in the department of neurosurgery of our hospital were statistically analyzed,in order to understand the distribution of intracranial infection strains and drug tolerance.Method：A total of 156 patients with postoperative intracranial infection were selected from the Department of neurosurgery in our hospital from 2013.1.1 to 2018.12.31,and the samples of cerebrospinal fluid were collected from the patients.The distribution and drug resistance of the patients in the cerebrospinal fluid culture examination and culture were statistically analyzed.Result：A total of 147 pathogens were cultured in 156 postoperative intracranial infection;62 strains of grampositive bacteria(42.2%),the main strains include staphylococcus aureus,staphylococcus epidermidis,coagulasenegative staphylococcus;84 strains of gramnegative bacteria(57.1%),the main strains include acinetobacter baumannii,pseudomonas aeruginosa,klebsiella pneumonia,enterobacter cloacae;1 strain of fungi(0.68%).The lower resistance rates among grampositive bacteria were piperacillin/tazobactam,linezolid,The drug resistance rate of vancomycin and tigecycline was 0.The rate of drug resistance is generally high in gramnegative,acinetobacter baumannii is resistant to most antibiotics,the resistance rate to polymyxin was 0.〖WTHZ〗Conclusion：Gramnegative bacteria of postoperative intracranial infection accounted for a larger proportion of grampositive bacteria,and the drug resistance rate in gramnegative bacteria is generally higher.Currently,piperacillin/tazobactam,linezolid or vancomycin is still effective against grampositive bacteria.Gramnegative bacteria are resistant to most antibiotics.polymyxin are still highly sensitive to it.

Key words: postoperative intracranial infection, bacteris distribution, drug resistance