Abstract: Objective：To explore the effect of enhanced recovery after surgery(ERAS) in perioperative period of elderly patients with locally advanced renal cell carcinoma(RCC).Methods：100 patients with locally advanced renal carcinoma admitted from June 2015 to June 2020 were randomly divided into control group(n=50) and ERAS group(n=50).The patients in the control group were given routine nursing during the perioperative period,and ERAS group was given measures related to ERAS on the basis of routine nursing.Postoperative first exhaust time,first defecation time,length of hospital stay,incidence of complications,readmission rate(within 30 days after discharge),nursing satisfaction,as well as pain degree and Creactive protein(CRP) level at 5 days after surgery were monitored in the two groups.Results：There were no statistically significant differences between the two groups in general conditions,operation time and intraoperative blood loss(P>0.05).ERAS group had significantly shorter postoperative exhaust time,first defecation time and hospital stay time than the control group(P＜0.01).There were no significant differences between the control group and ERAS group(P>0.05) in postoperative VAS score,CRP level and readmission rate 30 days after surgery.The complication rate of patients in the control group was significantly higher than that of ERAS group(P＜0.05),and the nursing satisfaction of patients in ERAS group was significantly higher than that of the control group(P＜0.05).Conclusion：ERAS in the perioperative period of elderly patients with locally advanced RCC can effectively promote postoperative rehabilitation of patients,reduce the incidence of complications and improve patient satisfaction.

Key words: enhanced recovery after Surgery, locally advanced renal cell carcinoma, elderly patients, perioperative period