Abstract: Objective To investigate the efficacy of BEIS combined with compound betasone in the treatment of lumbar disc herniation (LDH) and its influence on serum prostaglandin E2 (PGE2), tissue inhibitor of metalloproteinase-2 (TIMP-2) and tumor necrosis factor (TNF)-α levels.Methods Totally 116 LDH patients who received treatment in our hospital were served as the research subjects and stochastically grouped into intervertebral group and compound group through random number table.The intervertebral group used the BEIS technique via interlaminar endoscopy, while the compound group additionally received an injection of compound betamethasone.Two groups were compared in terms of 基金项目: 沧州市科学技术局研究课题(23244102059) 作者单位: 061000 河北沧州, 沧州市人民医院骨科 通信作者: 金忠军, Email: gnhs65@163.com [17]Wei W, Zheng X, Gu Y, et al.Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized-controlled trial [J].BMC Anesthesiol, 2022, 22(1): 1. [18]Zhu J, Wei B, Wu L, et al.Effect of Thoracic Paravertebral Block on Postoperative Pulmonary Complications After Video-Assisted Thoracoscopic Surgery: A Dual-Center Randomized Clinical Trial [J].Ther Clin Risk Manag, 2025, 21: 691-703. [19]Hassan J, Khan S, Zahra R, et al.Role of Procalcitonin and C-reactive Protein as Predictors of Sepsis and in Managing Sepsis in Postoperative Patients: A Systematic Review [J].Cureus, 2022, 14(11): e31067. [20]Xu W, Yu P, Wang X, et al.Comparative analysis of CRP and PCT as biomarkers for early diagnosis of pediatric septic arthritis: superior performance of CRP [J].Front Pediatr, 2025, 13: 1582978. [21]Zeng L, Yu X, Yang T, et al.The effect of ultrasound-guided thoracic paravertebral nerve block combined with hydromorphone on postoperative analgesia and inflammatory response in thoracoscopic surgery: a randomized controlled trial [J].Front Med (Lausanne), 2025, 12: 1587477. [22]GonzáLez P, Lozano P, Ros G, et al.Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections [J].Int J Mol Sci, 2023, 24(11): 352. (收稿日期: 2025-12-28) (本文编辑: 孙清源 杨泽平) therapeutic effect, pain, lumbar spine function, stress response, serum inflammatory factors, and complications.Results The total effective rate of the compound group was 94.83%, which was higher than the 81.03% of the intervertebral group (P<0.05).At 1 week and 3 months after surgery, both groups showed a decrease in pain scores, and the compound group had a lower pain score than the intervertebral group.Both groups showed an increase in lumbar spine function scores, and the compound group had a higher JOA score than the intervertebral group (P<0.05).On the day and 3 days after surgery, the compound group had lower adrenocorticotropic hormone (ACTH), cortisol (Cor), and norepinephrine (NE) than the intervertebral group (P<0.05).One week after surgery, the compound group had lower serum PGE2, TIMP-2, and TNF-α than the intervertebral group (P<0.05).The compound group and the intervertebral group had no great difference in complications (P>0.05).Conclusion The transforaminal endoscopic BEIS technique combined with compound betamethasone and compound betamethasone has good short-term curative effect in treating LDH patients.It can greatly reduce pain, improve lumbar spine function, inhibit stress response, downregulate inflammatory factors such as PGE2 and TIMP-2, control disease progression in a short period of time, and has high safety.

Key words: transforaminal endoscopic BEIS technology, compound betamethasone, lumbar disc herniation, pain, lumbar function