Abstract: Gallbladder cancer (GBC) is a relatively rare malignant tumor with poor prognosis,which is usually diagnosed in the late stage due to the lack of obvious early symptoms and specific clinical manifestations.Surgery is the only possible cure for gallbladder cancer,but the choice of surgical approach and scope is still controversial.In recent years, the application of targeted therapy and immunotherapy in advanced gallbladder cancer has brought new hope to patients.This article reviews the epidemiologic features,risk factors,pathologic characteristics,and current diagnostic and therapeutic strategies of gallbladder cancer,and discusses several controversial topics,aiming to provide a reference for clinical management.

Key words: gallbladder neoplasms;epidemiology;risk factors;surgical procedures