Abstract: Objective To explore the correlation between serum G protein signaling modulator 2 (GPSM2),adapter related protein complex 3 subunit mu2 (AP3M2) with clinical pathological features and postoperative prognosis of early colorectal cancer (CRC) patients.Methods From January 2020 to December 2021,142 early CRC patients (CRC group) and 96 colorectal polyp patients (benign lesion group) treated in our hospital were included,and 80 healthy volunteers (control group) were also included.RT-qPCR was used to detect serum GPSM2 and AP3M2.Kaplan-Meier survival curve was performed to analyze the relationship between serum GPSM2 and AP3M2 with the prognosis of CRC.Cox regression was performed to analyze the risk factors affecting the prognosis of CRC.ROC curve was used to explore the forecast value of serum GPSM2 and AP3M2 for the prognosis of CRC.Results The benign lesion group and CRC group had manifestly higher serum GPSM2 and AP3M2 than the control group,and with the CRC group being higher than the benign lesion group (P<0.05).Serum GPSM2 and AP3M2 in CRC patients were related to their differentiation degree (P<0.05).The 3-year survival rate of patients with low GPSM2 and AP3M2 was higher than that of patients with high GPSM2 and AP3M2 (85.29%、87.14% vs 67.57%、65.28%) (Log Rank χ²=7.205,10.800,P<0.05).Low differentiation degree and elevated serum GPSM2 and AP3M2 were risk factors affecting the prognosis of CRC (P<0.05).The AUC of serum GPSM2 and AP3M2 combined to predict the prognosis of CRC patients was 0.903 (Z_joint-GPSM2=2.882,Z_joint-AP3M2=3.322,P<0.05),the sensitivity is 88.24%,and the specificity is 82.41%.Conclusion The serum GPSM2 and AP3M2 in CRC patients are elevated and closely related to differentiation degree and prognosis.The joint of the two has high clinical value in forecasting the prognosis of CRC.

Key words: colorectal cancer;G protein signaling modulator 2;adapter related protein complex 3 subunit mu2;clinical pathological features;prognosis